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CASP2 — TFAP2A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TFAP2A → CASP2 (decreases) Nyormoi et al., Mol Cell Biol 2001*
  Evidence: Treatment of cells with inhibitors of Caspase 2 (zVDAVADfmk) and Caspase 8 (zLETDfmk), moderately prevented the downregulation of AP2 alpha expression and also had only a moderate effect on apoptosis.

Text-mined interactions from Literome

Nyormoi et al., Mol Cell Biol 2001 (Breast Neoplasms) : Cells transfected with green fluorescent protein tagged mutant AP-2alpha are resistant to TNF-alpha induced apoptosis, further demonstrating the link between caspase mediated cleavage of AP-2alpha and apoptosis
Gan et al., Acta Pharmacol Sin 2008 : Furthermore, overexpressing AP-2alpha increased the expression and activity of caspase-3 , whereas antisense AP-2alpha in part abolished the increased effects of doxazosin on caspase-3 expression and activity