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CHUK — EPHB2
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Chen et al., Br J Pharmacol 2001
:
PKC- and
ERK dependent activation of
I kappa B kinase by lipopolysaccharide in macrophages : enhancement by P2Y receptor mediated CaMK activation
Afaq et al., Int J Cancer 2005
(Edema...) :
We also found that topical application of PFE resulted in inhibition of TPA induced phosphorylation of
ERK1/2 , p38 and JNK1/2, as well as
activation of NF-kappaB and
IKKalpha and phosphorylation and degradation of IkappaBalpha
Maeng et al., Cell Signal 2006
:
Consistently, inhibition of
ERK significantly
increased IkappaB kinase (IKK) activity, IkappaBalpha phosphorylation, and nuclear translocation of NF-kappaB induced by VEGF, whereas overexpression of ERK resulted in the loss of these responses to VEGF
Shan et al., Am J Physiol Lung Cell Mol Physiol 2006
(Asthma...) :
Complementary studies further demonstrated that the ASM responses to LPS were associated with activation of the ERK1/2 and p38 MAPK signaling pathways,
IKK mediated
activation of NF-kappaB, and coupling of phosphorylated
ERK1/2 with the p65 subunit of NF-kappaB
Huang et al., Biochem Pharmacol 2007
(Lung Neoplasms) :
The SDF-1alpha mediated increases in
IKK alpha/beta phosphorylation, p65 Ser ( 536 ) phosphorylation, and kappaB-luciferase activity were
inhibited by PD98059 and
ERK2 mutant
Otipoby et al., Proc Natl Acad Sci U S A 2008
:
BAFF activates Akt and
Erk through BAFF-R in an
IKK1 dependent manner in primary mouse B cells
Leghmari et al., Eur J Cell Biol 2008
:
We demonstrate that, upstream of NF-kappaB, PKC,
ERK1/2 and p38 MAP kinases are
involved in Tat induced
IKKalpha nuclear translocation and histone H3 modifications on the IL-10 promoter in accordance with the role of these three kinases in IL-10 production
Chen et al., TheScientificWorldJournal 2010
:
Blocking phosphorylation of
ERK1/2 by MAPK inhibitors U0126 and PD98059, and
inhibiting activation of NF-?B by
IkappaB ( I?B ) kinase inhibitors wedelolactone or IMD-0354, abolished the DSP effects
Yang et al., Mol Cell Biol 2012
:
Unexpectedly, TPL-2 promoted soluble TNF production independently of
IKK induced p105 phosphorylation and its ability to activate
ERK , which has important implications for the development of anti-inflammatory drugs targeting TPL-2
Slomiany et al., Inflammopharmacology 2013
:
Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on
MAPK/ERK mediated
activation of
IKK-ß and cPLA2 : modulatory effect of ghrelin
Lee et al., Proc Natl Acad Sci U S A 1998
:
We have previously shown that mitogen activated protein
kinase/ERK kinase kinase 1 ( MEKK1 ) can
induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight
IkappaB kinase complex in vitro