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HSD11B2 — TNF

Text-mined interactions from Literome

Handoko et al., J Steroid Biochem Mol Biol 2000 : Northern blot analysis revealed corresponding changes in the level of 11beta-HSD1 mRNA, suggesting that the effects of TNFalpha and insulin on 11beta-HSD1 activity are mediated at the level of gene transcription
Cooper et al., J Bone Miner Res 2001 (Inflammation...) : In MG-63 cells, interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) potently inhibited 11beta-HSD2 activity ( cortisol-cortisone conversion ) and messenger RNA ( mRNA ) levels in a dose dependent manner while stimulating reciprocal expression of 11beta-HSD1 mRNA and activity ( cortisone-cortisol conversion )
Heiniger et al., FEBS Lett 2001 : The effect of TNF-alpha on 11beta-HSD2 was reversed by inhibiting the mitogen activated protein kinases ERK with PD-098050 and p38 by SB-202190, or by activating protein kinase A with forskolin
Friedberg et al., J Clin Endocrinol Metab 2003 : TNF alpha up-regulated 11 beta-HSD-1 activity maximally at 0.6 x 10 ( -9 ) M ( 140 +/- 20 % ; P < 0.001 ) ; the same cytokine increased 11 beta-HSD-1 mRNA levels to 3-fold of control ( P < 0.05 ) and increased medium glycerol levels to 165 +/- 14 % of control ( P < 0.01 )
Kostadinova et al., FASEB J 2005 : The analysis of the transcriptional regulation of 11beta-HSD2 by TNF-alpha and phorbol 12-myristate-13-acetate ( PMA ) with in vivo genomic footprinting in human colon SW620 cells revealed stimulus dependent protein-DNA interactions in three promoter regions, kappaB1, Sp1/Egr-1I, and Sp1/Egr-1II
Johnstone et al., J Soc Gynecol Investig 2005 (Chorioamnionitis...) : In JEG-3 cells, 11beta HSD-1 32-kd expression was increased with interleukin (IL)-1beta and tumor necrosis factor alpha (TNF-alpha) , while 11beta HSD-2 expression was unaffected
Chisaka et al., J Soc Gynecol Investig 2005 (Choriocarcinoma...) : Therefore, we have evaluated the effect of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) on 11beta-HSD2 in cultured human placental trophoblast and in human choriocarcinoma JEG-3 cells ... In placental trophoblast, TNF-alpha and IL-1beta down-regulated 11beta-HSD2 mRNA expression and activity ( both P < .05 )
Suzuki et al., Tohoku J Exp Med 2005 : Likewise, tumor necrosis factor (TNF)-alpha inhibited both activity and mRNA expression of 11beta-HSD2
Tsugita et al., Life Sci 2008 : Interestingly, the transcriptional activity of 11beta-HSD-1 was stimulated by a representative proinflammatory cytokine TNFalpha , and inflammation related inducible transcription factors AP1 and C/EBPs might have been at least partly responsible for the effect
Ignatova et al., Am J Physiol Endocrinol Metab 2009 (Carcinoma, Hepatocellular...) : To dissect the molecular mechanism of this increase, we investigated basal and TNF-alpha induced transcription of the 11beta-HSD1 gene ( HSD11B1 ) in HepG2 cells ... In conclusion, C/EBPalpha and C/EBPbeta control basal transcription, and TNF-alpha upregulates 11beta-HSD1 , most likely by p38 MAPK mediated increased binding of C/EBPbeta to the human HSD11B1 promoter ... To our knowledge, this is the first study showing involvement of p38 MAPK in the TNF-alpha mediated 11beta-HSD1 regulation, and that TNF-alpha stimulates enzyme activity in vivo