Gene interactions and pathways from curated databases and text-mining

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FOXO3 — TNF

Text-mined interactions from Literome

Abid et al., J Biol Chem 2005 (Hyperplasia) : PDGF-BB, tumor necrosis factor-alpha , and insulin-like growth factor 1 treatment resulted in the nuclear exclusion of FoxO , whereas PDGF-BB alone down-regulated the FoxO target gene, p27 ( kip1 ), and enhanced cell survival and progression through the cell cycle
Moylan et al., Am J Physiol Cell Physiol 2008 : We used TNF treated C2C12 myotubes to test the hypothesis that AKT-Foxo1/3 signaling mediates TNF regulation of atrogin mRNA
Dejean et al., Nat Immunol 2009 (Arenaviridae Infections) : Stimulation of dendritic cells mediated by the coinhibitory molecule CTLA-4 induced nuclear localization of Foxo3 , which in turn inhibited the production of interleukin 6 and tumor necrosis factor
Snoeks et al., Lab Invest 2009 (Colitis...) : TNFalpha induces the translocation of nuclear FOXO3 into the cytosol where it undergoes proteasomal degradation in human intestinal HT-29 cells
Sheriff et al., Mol Cell Endocrinol 2012 (Burns...) : DAG also reversed or attenuated the TNF+IFN induced reduction in phosphorylation of Akt, FOXO1 , 4E-BP-1, and GSK-3ß in myotubes
Lin et al., J Endod 2013 : We assessed tumor necrosis factor (TNF)-a stimulated expression of Cyr61 and phosphorylated inactive FoxO3a ( p-FoxO3a ) in MC3T3-E1 murine osteoblasts by Western analysis
Tang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2013 : TNF-a also significantly activated the phosphorylation of PTEN, AKT and FOXO3a ( P < 0.05 )