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H2AFX — RBBP7

Text-mined interactions from Literome

Zhang et al., Int J Radiat Oncol Biol Phys 2006 : To explore their effects on ionizing radiation ( IR ), we examined whether the HDAC inhibitors m-carboxycinnamic acid bis-hydroxamide ( CBHA ) and depsipeptide FK228 affect H2AX phosphorylation ( gamma-H2AX ), a landmark of DNA double-strand breaks after IR exposure ... The results of this study suggest that HDAC inhibitors enhance IR-induced gamma-H2AX , most likely through histone hyperacetylation, and radiosensitize various cancers
Ozaki et al., Cancer Sci 2008 : HDAC inhibitors potentiated both the phosphorylation of histone H2AX on serine-139 ( a marker of DNA double-strand breaks ) as well as the accumulation of reactive oxygen species induced by DNA damaging agents in tumor cells