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PDLIM7 — RB1

Text-mined interactions from Literome

Ding et al., J Med Virol 2007 : In this study, it was indicated that LMP1 inhibited p16(INK4A) expression, promoted phosphorylation of p105 Rb and upregulated E2F1 expression as well as transactivation, and overexpression of E2F1 alone was sufficient to upregulate telomerase activity
Arvanitakis et al., J Immunol 1995 (Burkitt Lymphoma...) : Taken together, these data point to a potential mechanism underlying EBV mediated B cell transformation whereby constitutive induction of key cell cycle regulators by LMP-1 can lead to pRb hyperphosphorylation and uncontrolled cell proliferation