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NPY4R — RB1
Text-mined interactions from Literome
Tamrakar et al., Oncogene 1999
:
Similar binding studies performed with toxin inhibited PP1 indicate that catalytic activity of
PP1 is not
required for
pRB binding
Dunaief et al., Curr Eye Res 2002
:
Conversely,
PP1 activity may be specifically
regulated by
pRb and not p107 or p130
Berndt et al., Methods Mol Biol 2004
(Bone Neoplasms...) :
While the regulation of pRb by cyclin dependent kinases (Cdks) has been studied extensively, the
role ( s ) of protein
phosphatase 1 (PP1) in controlling
pRb are only partially understood ... Methods will be presented to study the cell cycle dependent dephosphorylation of pRb by various PP1 isozymes, the specificity of PP1 isozymes for distinct pRb phosphorylation sites, the dephosphorylation of pRb associated with apoptosis, and the cell cycle- and
pRb dependent phosphorylation of
PP1
Liu et al., Mol Carcinog 2006
(Cell Transformation, Neoplastic) :
Both PP1alpha mediated G ( 1 ) arrest and
PP1alpha phosphorylation in late G ( 1 )
require the presence of
pRb , indicating that PP1alpha is a crucial regulator of the pRb pathway, which is almost invariably mutated in human cancer