◀ Back to INSR
INSR — PTPRF
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
INSR
→
PTPRF
(decreases, PTPRF Activity, INSR Activity)
Evidence: Overexpression of these enzymes [LAR and PTP1B] in cultured cells prevents insulin receptor kinase activation.
-
KEGG Insulin signaling pathway:
PTPRF
→
INSR
(protein-protein, inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Hprd Interaction:
PTPRF
—
INSR
(in vivo)
Tsujikawa et al., Mol Endocrinol 2001*, Hashimoto et al., J Biol Chem 1992, Blanchetot et al., Methods 2005
-
IRef Hprd Interaction:
PTPRF
—
INSR
(in vitro)
Tsujikawa et al., Mol Endocrinol 2001*, Hashimoto et al., J Biol Chem 1992, Blanchetot et al., Methods 2005
-
IRef Ophid Interaction:
PTPRF
—
INSR
(aggregation, confirmational text mining)
Hashimoto et al., J Biol Chem 1992
-
IRef Ophid Interaction:
PTPRF
—
INSR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
STRING interaction:
INSR
—
PTPRF
(interaction, mapped from kegg_pathways)
-
STRING interaction:
INSR
—
PTPRF
(interaction, mapped from kegg_pathways)
-
STRING interaction:
PTPRF
—
INSR
(interaction, mapped from kegg_pathways)
-
STRING interaction:
PTPRF
—
INSR
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Kole et al., J Basic Clin Physiol Pharmacol 1998
(Insulin Resistance) :
Inhibition of the transmembrane protein tyrosine phosphatase
lar by 3S-peptide-I
enhances insulin receptor phosphorylation in intact cells ... Increased
LAR expression
resulted in 40 % reduction in ligand mediated phosphorylation of the
insulin receptor compared with null vector control ( p < 0.001 )
Glover et al., Biochem Cell Biol 2000
:
LAR also is
involved in regulation of the
insulin receptor while CD45 is critical for T-cell activation
Kulas et al., J Biol Chem 1995
:
Insulin receptor signaling is
augmented by antisense inhibition of the protein tyrosine phosphatase
LAR ... These studies provide unique in vivo evidence that
LAR is
involved in the modulation of
insulin receptor signaling in intact cells