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EPHB2 — PTHLH

Text-mined interactions from Literome

Hoey et al., Br J Cancer 2003 (Bone Neoplasms...) : PTHRP induced weak activation of ERK1 and ERK2 and potentiated their activation by serum growth factors
Chen et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Most interesting, a bidirectional effect was found with PTHrP increasing phosphorylated ERK in undifferentiated MC4 cells but decreasing phosphorylated ERK in differentiated cells
Shimo et al., J Bone Miner Res 2006 (Bone Neoplasms...) : Consistent with these findings, inhibition of PKC prevented PTHrP induced ERK1/2 activation, whereas 12-O-tetradecanoylphorbol13-acetate ( TPA ), a stimulator of PKC, upregulated it ... CCN2 was critically involved in osteolytic metastasis and was induced by PKA- and PKC dependent activation of ERK1/2 signaling by PTHrP
Reyes-Ibarra et al., Mol Endocrinol 2007 (Calcium Signaling) : Interestingly, this Rab11a dominant negative mutant does not interfere with CaR dependent activation of ERK 1/2, suggesting that ERK signaling is not sufficient to promote PTHrP secretion downstream of CaR
Hastings et al., Am J Physiol Lung Cell Mol Physiol 2009 (Adenocarcinoma...) : Ectopic expression of PTHrP stimulated ERK phosphorylation ... In MV522 cells, PTHrP had similar effects on DNA synthesis, cyclin A2 expression, pRb levels, CDK2-cyclin A2 association, and ERK activation
Datta et al., Cell Signal 2010 : In this study we investigate the role of MAPK phosphatase-1 (MKP-1) in PTHrP regulation of ERK1/2 activity in relation to osteoblast proliferation, differentiation and bone formation
Ardura et al., J Am Soc Nephrol 2010 (Disease Models, Animal...) : Inhibition of EGFR activation abolished these EMT related changes, the activation of ERK1/2 , and upregulation of TGF-beta1 and VEGF by PTHrP ( 1-36 )