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EPHB2 — OSM

Text-mined interactions from Literome

Van Wagoner et al., J Neurochem 2000 (Astrocytoma) : Finally, we show that the MAPKs ERK1/2 and p38 are activated by OSM in astrocytes and that this activation is reduced by the MAPK inhibitors
Li et al., J Immunol 2001 : OSM induced ERK1/2 activation was also not affected by these inhibitors
Song et al., Int J Biochem Cell Biol 2005 (MAP Kinase Signaling System) : OSM treatment induced phosphorylation of ERK , and pretreatment with U0126, a MEK inhibitor, prevented the OSM stimulated proliferation of hATSCs, suggesting that the MEK/ERK pathway is involved in the OSM induced proliferation ... Furthermore, OSM treatment elicited phosphorylation of STAT1 and STAT3, and pretreatment with WHI-P131 specifically prevented the OSM induced phosphorylation of STAT1, without affecting the OSM induced phosphorylation of ERK and STAT3
Song et al., J Cell Biochem 2007 : OSM treatment induced activation of JAK2, JAK3, and ERK in hADSCs, and pre-treatment of hADSCs with the JAK2 inhibitor, AG490, significantly restored the OSM induced inhibition of adipogenic differentiation
Pollack et al., American journal of physiology. Renal physiology 2007 (MAP Kinase Signaling System) : Besides inducing phosphorylation of Stat1 and Stat3, OSM led to a strong concentration- and time dependent phosphorylation of the mitogen activated protein kinases ERK1 , ERK2, and ERK5 ... MEK1/2 inhibitor U0126 ( 10 muM ) blocked basal and OSM induced ERK1/2 phosphorylation but not phosphorylation of either ERK5 or Stat1/3
Li et al., PloS one 2011 : Exogenous CNTF, CT1, or OsM induces STAT3 phosphorylation, and OsM also induces the phosphorylation of ERK1/2 ( p44/42 MAP kinase )
Faris et al., AIDS 1996 (AIDS-Related Opportunistic Infections...) : OSM also induced the activation of ERK2 by activating the serine/threonine kinases Raf-1 and [ mitogenactivated protein kinase ( MAPK ) ERK kinase ( MEK1 ) ] -1, while bFGF failed to activate any of the above components