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ADAM10 — SIRT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
SIRT1
—
ADAM10
(interaction, mapped from intact)
-
STRING interaction:
ADAM10
—
SIRT1
(interaction, mapped from intact)
Text-mined interactions from Literome
Donmez et al., Cell 2010
(Alzheimer Disease) :
ADAM10 activation by
SIRT1 also induces the Notch pathway, which is known to repair neuronal damage in the brain
Bonda et al., Lancet Neurol 2011
(Alzheimer Disease) :
Mechanistically,
SIRT1 increases a-secretase production and activity through activation of the a-secretase gene
ADAM10