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NFKBIB — TNF

Text-mined interactions from Literome

Alpert et al., J Biol Chem 1999 : We demonstrate that NaSal similarly inhibits TNF induced IkappaBbeta degradation in a p38 dependent manner
Algül et al., Am J Physiol Gastrointest Liver Physiol 2002 : Tumor necrosis factor-alpha mediated IKK activation leads to IkappaBalpha and IkappaBbeta degradation
De Plaen et al., Immunology 2002 : We found that TNF causes rapid degradation of IkappaBalpha and IkappaBbeta
Murao et al., Virology 2005 : This ability was attributed to blockage of the persistent phase of TNF-alpha induced NF-kappaB activation for the following reasons : ( 1 ) the initial phase of NF-kappaB transcriptional activation was not affected by the MC159 protein ; ( 2 ) the MC159 protein inhibited TNF-alpha directed degradation of IkappaBbeta , but not IkappaBalpha ; and ( 3 ) expression of the late NF-kappaB regulated cell genes, TNF-alpha and CCL2, was decreased in the presence of the MC159 protein while transcription of the early NF-kappaB regulated cell gene, CXCL1, was not altered
Laskov et al., Eur Cytokine Netw 2005 (Burkitt Lymphoma...) : Our results thus show that in Ramos cells, TNF-alpha and CD40L have common, as well as differential, signaling effects on the IkappaBalpha, IkappaBbeta and IkappaBepsilon, which form inhibitory complex ( es ) with the NF-kappaB cytosolic proteins
Funakoshi-Tago et al., Biochem Pharmacol 2008 : Here, we found that Celecoxib potently inhibited TNFalpha induced transcriptional activity and DNA binding activity of NF-kappaB ; however, Celecoxib had no effect on TNFalpha induced IKK activation and degradation of IkappaBalpha and IkappaBbeta , suggesting that it inhibited NF-kappaB activation via suppressing downstream of IKK activation and IkappaBs degradation
Young et al., Bone 2010 : In addition we determined that TNF-alpha treatment did not induce the degradation of IkappaBbeta as did OFF
Rao et al., Nature 2010 (Arthritis, Experimental) : Surprisingly, absence of IkappaBbeta results in a dramatic reduction of TNF-alpha in response to LPS even though activation of NF-kappaB is normal
Harhaj et al., J Biol Chem 1997 : The calyculin A-mediated degradation of IkappaBbeta is further enhanced by the cytokine tumor necrosis factor-alpha (TNF-alpha) , although TNF-alpha alone is unable to induce the degradation of IkappaBbeta ... Mutational analyses have revealed that the inducible degradation of IkappaBbeta induced by calyculin A, and TNF-alpha requires two N-terminal serines ( serines 19 and 23 ) that are homologous to the inducible phosphorylation sites present in IkappaBalpha
Krappmann et al., Immunobiology 1997 : TNF-alpha signaling leads to a rapid depletion of cellular I kappa B beta pools
Weil et al., Immunobiology 1997 : Here we show that in E29.1 T cell hybridoma I kappa B alpha and I kappa B beta are equally associated with p65 and that I kappa B beta is degraded in response to TNF alpha in contrast to what has been originally published
You et al., J Virol 1999 : Furthermore, the HCV core protein enhanced or prolonged the IkappaB-beta degradation triggering by TNF-alpha or LT-alpha1beta2 both in HeLa and HuH-7 cells