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CFLAR — TNF

Text-mined interactions from Literome

Yeh et al., Immunity 2000 : NF-kappaB and JNK/SAPK activation is intact in TNF stimulated casper-/- cells
Kreuz et al., Mol Cell Biol 2001 : Treatment of SV80 cells with the proteasome inhibitor N-benzoyloxycarbonyl ( Z ) -Leu-Leu-leucinal ( MG-132 ) or geldanamycin, a drug interfering with tumor necrosis factor (TNF) induced NF-kappaB activation, inhibited TNF induced upregulation of cFLIP
Okano et al., Lab Invest 2003 (Carcinoma, Hepatocellular...) : cFLIP expression was increased by TNF-alpha , TRAIL, or vascular endothelial growth factor but decreased by wortmannin, indicating that cFLIP expression is regulated by both the NF-kappaB and phosphatidylinostiol-3 kinase (PI-3)/Akt pathways
Yang et al., Invest Ophthalmol Vis Sci 2005 : TRAF-1, c-FLIP , and to a lesser extent c-IAP2 protein levels were increased by TNF-alpha in a time dependent manner, whereas c-IAP1, survivin, Bcl-x ( L ), and TRAF-2 protein levels were not influenced by TNF-alpha treatment at any time point tested ... Overexpression of mutant IkappaB blocked TNF-alpha induced TRAF-1, TRAF-2, c-IAP1, c-IAP2, c-FLIP , and A1 gene expression and downregulated TRAF-1 protein levels
Ahn et al., Cancer Res 2007 (Skin Neoplasms) : The induction of various antiapoptotic gene products ( MMP-9, cyclin D1, COX-2, IAP1, IAP2, Bcl-2, cFLIP , and XIAP ) by TNF was also abolished in NQO2-/- cells
O'Gorman et al., Am J Physiol Gastrointest Liver Physiol 2010 : The induction of the chemokine interleukin-8 and the antiapoptotic protein cFLIP by tumor necrosis factor-alpha were markedly less in HCT116 cells lacking DNMT than in parental cells