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LEP — RENBP
Text-mined interactions from Literome
Lee et al., J Cell Biochem 2004
:
We concluded that
AGE induced JAK2 to increase
leptin while leptin induced JAK2 to increase CTGF induced mitogenesis and type I collagen protein expression in NRK-49F cells
Horiuchi et al., Ann N Y Acad Sci 2005
(Diabetic Nephropathies) :
In this study, we focused on two AGE receptors-specifically, the role of SR-A in pathogenesis of diabetic nephropathy and the role of CD36 in
AGE induced downregulation of
leptin by adipocytes ...
AGE induced downregulation of
leptin was protected by N-acetyl-cysteine, an antioxidant
Unno et al., Ann N Y Acad Sci 2005
(Metabolic Syndrome X) :
The purpose of this study was to examine
effects of
AGE ligands on
leptin expression in adipocytes ... These results indicate that the ligand interaction of GA-BSA with CD36 leads to downregulation of leptin expression in 3T3-L1 adipocytes, suggesting that
AGE induced
leptin downregulation is linked to reduction of the insulin sensitivity in metabolic syndrome