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CXCR4 — TAT

Text-mined interactions from Literome

Litovchick et al., Biochemistry 2001 : Here we present a novel HIV-1 Tat antagonist, a neomycin B-hexaarginine conjugate ( NeoR ), which inhibits Tat transactivation and antagonizes Tat extracellular activities, such as increased viral production, induction of CXCR4 expression, suppression of CD3 activated proliferation of lymphocytes, and upregulation of the CD8 receptor
Gibellini et al., Clin Exp Immunol 2003 : Selective up-regulation of functional CXCR4 expression in erythroid cells by HIV-1 Tat protein
Mondal et al., Experimental biology and medicine (Maywood, N.J.) 2005 : The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells ... In PMA stimulated cells, Tat increased CXCR4 and decreased in CCR5 expression, this was potentiated in cells chronically exposed to Tat
Hidalgo-Estévez et al., Mol Immunol 2008 : We have investigated the role of intracellular HIV-1 Tat on CXCR4 expression on T cells ... We found that stable or doxycycline regulated expression of HIV-1 Tat on Jurkat T cells results in lower cell surface expression of CXCR4 , but not of other chemokine receptors
Huang et al., J Virol 1998 (HIV Infections) : Moreover, Tat induced CXCR4 and CCR5 expression was dose dependent ... Monocytes/macrophages were more susceptible to Tat mediated induction of CXCR4 and CCR5 than lymphocytes, and CCR5 was more readily induced than CXCR4