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FOXO1 — IGF1
Text-mined interactions from Literome
Guo et al., J Biol Chem 1999
:
Reporter gene studies in HepG2 hepatoma cells show that
FKHR stimulates
insulin-like growth factor binding protein-1 promoter activity through an IRS, and introduction of IRSs confers this effect on a heterologous promoter
Ayalon et al., Growth Horm IGF Res 2001
(Osteosarcoma...) :
In the present study the potential
regulation of the
IGF-I receptor (IGF-I-R) gene by
PAX3-FKHR at the transcriptional level was investigated ...
PAX3-FKHR was able to
transactivate the
IGF-I-R promoter in sarcoma derived cell lines, whereas PAX3 exhibited a reduced potency in comparison to the fusion protein
Richards et al., Mol Endocrinol 2002
:
In naïve granulosa cells, both FSH and
IGF-I stimulate rapid phosphorylation of
FKHR at multiple sites causing its redistribution from the nucleus to the cytoplasm in a PI3K dependent manner
Li et al., Mol Cell Biochem 2002
(MAP Kinase Signaling System) :
Des
IGF-I increased the phosphorylation of the transcription factor
FKHR in cardiac muscle only ( p < 0.05 )
Liu et al., Endocrinology 2002
:
IGF-I increased the phosphorylation of glycogen synthase kinase 3beta, BAD,
FKHR , and p70 ( S6 ) kinase
Kim et al., Biol Reprod 2003
:
Regulation of
insulin-like growth factor binding protein-1 promoter activity by
FKHR and HOXA10 in primate endometrial cells
Rena et al., EMBO Rep 2004
:
Our results indicate that these residues are targeted by CK1 in vivo and that the CK1 mediated phosphorylation of the MPD is required for accelerated nuclear exclusion of
FOXO1a in
response to
IGF-1 and insulin
Schwab et al., Apoptosis 2005
(Neuroblastoma) :
IGF-I induced phosphorylation of Erks ( p42/p44 ),
FKHR ( FOXO1a ) ( Ser 253 ), FKHRL1 ( FOXO3a ) ( Ser 256 ), and Akt ( Ser 473 ) ... PI3-K inhibitor, LY294002, reduced
IGF-I stimulated phosphorylation of
FKHR , FKHRL1, and Akt, but did not affect Erk phosphorylation
Liu et al., J Endocrinol 2007
:
Inhibition of phosphatidylinositol 3-kinase/Akt pathway suppressed the
effect of insulin and
IGF-I on
FOXO1 phosphorylation
Hansen et al., PLoS Genet 2008
:
Long lived daf-2
insulin/IGF-1 receptor mutants
require both autophagy and the transcription factor
DAF-16/FOXO for their longevity, but we find that autophagy takes place in the absence of DAF-16
Essaghir et al., J Biol Chem 2009
:
PDGF, fibroblast growth factors ( FGF ), and
IGF-I repressed the expression of
FOXO genes in human fibroblasts
Srivastava et al., Int J Oncol 2009
(Cerebellar Neoplasms...) :
IGF-I stimulation of serum starved cells
resulted in rapid phosphorylation of Akt and
FOXO1 , and was associated with a significant increase in cell viability
Cleveland et al., Am J Physiol Regul Integr Comp Physiol 2010
:
IGF-I and insulin
stimulated phosphorylation of
FOXO1 and FOXO4 ( P < 0.05 ), which was inhibited by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin, and decreased the abundance of polyubiquitinated proteins by 10-20 % ( P < 0.05 )
Kenyon et al., Ann N Y Acad Sci 2010
:
However, the mechanisms by which inhibition of
insulin/IGF-1 signaling and germline loss
activate DAF-16/FOXO are distinct
Löw et al., Gen Comp Endocrinol 2011
(Nerve Degeneration) :
Longevity increases when
FoxO becomes activated in
response to reduced
insulin/IGF-1 signalling
Sengupta et al., Circ Res 2013
:
In vivo, combined loss of
FoxO1 and FoxO3 specifically in cardiomyocytes
leads to delayed cell-cycle withdrawal and increased expression of
IGF1 and FoxM1