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EPHB2 — P2RX7

Text-mined interactions from Literome

Amstrup et al., Biochem J 2003 : P2X7 receptor activates extracellular signal regulated kinases ERK1 and ERK2 independently of Ca2+ influx ... Stimulation of P2X7 receptors in HEK-293 cells led to an activation of extracellular signal regulated kinases ERK1 and ERK2 and this activation was seen after just 1 min of stimulation with ATP ... In cell suspensions prepared from rat pancreas we show that P2X7 receptors also activate ERK1 and ERK2, indicating that these signalling pathways are also turned on in native epithelium
Stefano et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca ( 2+ ) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1
D'Alimonte et al., Int J Immunopathol Pharmacol 2007 : P2X(7) induced ERK1/2 phosphorylation was unaffected by pre-treatment of astrocytes with EGTA whereas it was inhibited by GF109203X
Kawano et al., Biochem Biophys Res Commun 2012 : P2X4-knockdown cells, established by transfecting RAW264.7 cells with two short hairpin RNAs ( shRNAs ) targeting P2X4 receptor, showed a decrease of the initial peak of intracellular Ca ( 2+ ) after treatment with ATP, though pore formation and the P2X7 mediated activation of ERK1/2 and p38 MAPK were not affected
Wickert et al., PloS one 2013 : Alanine substitutions near or within these sequences were constructed, and we determined that single mutation of R574 and R578 but not R576 or K579 attenuates P2X7 stimulated activation of ERK1/2 and induction of the transcription factors FosB and dFosB
Tsao et al., Cell death & disease 2013 : PKC dependent ERK phosphorylation is essential for P2X7 receptor mediated neuronal differentiation of neural progenitor cells ... Furthermore, stimulation of P2X7R induced activation of ERK1/2 , which was inhibited by the removal of extracellular Ca ( 2+ ) and treatment with blockers for P2X7R and PKC activity ... Stimulation of P2X7R also induced translocation of PKCa and PKC?, but not of PKCß, whereas knockdown of either PKCa or PKC? inhibited ERK1/2 activation