We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to SOS1

IGF1R — SOS1

Pathways - manually collected, often from reviews:

  • BioCarta multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta/14-3-3 complex (IGF1R-YWHAH-IGF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • BioCarta the igf-1 receptor and longevity: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • BioCarta igf-1 signaling pathway: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta complex (IGF1-IGF1R) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC mu (PRKD1) (modification, activates) Hermanto et al., Mol Cell Biol 2002
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GTP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: GRB2/SOS1 complex (GRB2-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) (modification, collaborate)
    Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → RACK1 (GNB2L1) (modification, collaborate) Hermanto et al., Mol Cell Biol 2002, Kiely et al., J Biol Chem 2005
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 complex (IGF1R-IGF1-IRS1-GNB2L1-GRB2-SHC1-SOS1) → PKC delta (PRKCD) (modification, activates) Hermanto et al., Mol Cell Biol 2002
    Evidence: assay, physical interaction
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: GRB2/SOS1/SHC complex (GRB2-SOS1-SHC1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) → IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) (modification, collaborate)