Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kobayashi et al., J Biol Chem 2001 (MAP Kinase Signaling System...) : PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun dependent uPA expression
Okan et al., Oncogene 2001 : The small-GTPase RalA activates transcription of the urokinase plasminogen activator receptor ( uPAR ) gene via an AP1 dependent mechanism
Kobayashi et al., Hum Cell 2001 (MAP Kinase Signaling System...) : We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase, since PMA could also activate a signaling pathway involving MEK/ERK/c-Jun dependent uPA expression
Das et al., J Biol Chem 2004 (Breast Neoplasms...) : However, the role ( s ) of OPN on AP-1 mediated uPA secretion and cell motility and the involvement of c-Src/epidermal growth factor receptor (EGFR) in these processes in breast cancer cells are not well defined ... To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells
Amos et al., J Neuropathol Exp Neurol 2010 (Glioblastoma...) : In summary, these results suggest that c-Src, mitogen activated protein kinase, and a composite activator protein 1 on the uPA promoter are responsible for EGF induced uPA expression and GBM invasion
Huang et al., J Cell Physiol 2012 (Colorectal Neoplasms...) : Inhibition of Sp1 and AP-1 activation blocked the SDF-1 induced expression and activity of the uPA promoter
Lee et al., J Biol Chem 1994 : DNA-protein interaction studies, together with mRNA and protein analyses, indicate that c-Jun , but not c-Fos, is involved in OA-dependent uPA gene induction
Lee et al., Nucleic Acids Res 1993 : Here we show that the induction of the uPA gene by CSR is mediated by the activation of c-Jun which interacts with an AP-1-like site located 2 kb upstream of the uPA gene
Dear et al., FEBS Lett 1997 (Fibrosarcoma...) : Since transcription factors bound to AP-1 recognition sequences within the PAI-2 gene promoter play a role in basal and phorbol ester mediated induction of PAI-2 gene expression, we hypothesised that u-PA/u-PAR mediated modulation of AP-1 activity would in turn influence constitutive and inducible PAI-2 gene expression
Miralles et al., Mol Cell Biol 1998 : This activation links external UV stimulation and AP1 dependent uPA transcription, providing a transcription coupled signal transduction pathway for the induction of the murine uPA gene by UV