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BMP2 — MMP2
Text-mined interactions from Literome
Nakashima et al., Frontiers in bioscience : a journal and virtual library 2006
:
In these cultures,
MMP-13 mRNA expression was
induced by
BMP-2 in Wnt3a over expressing C2C12 ( Wnt3a-C2C12 ) cells but not in either Wnt5a over expressing C2C12 ( Wnt5a-C2C12 ) cells or vehicle transfected C2C12 cells ... However, membrane type-1 matrix metalloproteinase ( MT1-MMP ) and
MMP-2 mRNA expression was not
affected by either Wnt3a or
BMP-2
Kumagai et al., Anticancer Res 2006
(Carcinoma...) :
Gel zymography for matrix metalloproteinases ( MMPs ) and urokinase-type plasminogen activator ( uPA ) detection revealed that
BMP-2 down-regulated the activity of MMP-9, but not of
MMP-2 or uPA ...
BMP-2 also reduced the secretion of MMP-9 into the culture media, but did not
affect the secretion of
MMP-2 , Timp-1, Timp-2 or Timp-3
Tang et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008
(Lung Neoplasms...) :
To explore the
effect of
bone morphogenetic protein-2 (BMP-2 ) on the expression of membrane Type 1-matrix metalloproteinase ( MT1-MMP ) and the activation of
matrix metalloproteinase-2 (MMP-2) in human A549 lung carcinoma cells ...
BMP-2 dose-dependently
activated MMP-2 in A549 cells ...
BMP-2 might
promote MT1-MMP expression and
MMP-2 activation in lung carcinoma cells, which can lead to the increase of extracellular matrix followed by acceleration of tumor cell migration and invasion
Gordon et al., Carcinogenesis 2009
(Neoplasm Invasiveness...) :
Further, Smad1 is required for BMP induced invasiveness and partially responsible for
BMP mediated increases in
MMP-2 activity
Hu et al., Molecular vision 2008
:
We examined BMP-2 expression in human scleral fibroblasts ( HSF ) and assessed the
effects of recombinant human
BMP-2 ( rhBMP-2 ) on HSF proliferation,
matrix metalloproteinase-2 (MMP-2) , and tissue inhibitor of metalloproteinase-2 ( TIMP-2 )
Fukui et al., Anat Rec (Hoboken) 2010
:
The aim of this study is to investigate whether
BMP-2 regulates the oral sulcus formation of mouse embryonic tongue by modifying the expression of TIMP and
MMP
Liu et al., Frontiers in bioscience (Landmark edition) 2012
(MAP Kinase Signaling System...) :
Our data show that stimulation of PANC-1 cells with
BMP2 induced
MMP-2 secretion and activation, associated with decreased E-cadherin expression, resulting in epithelial-to-mesenchymal transformation ( EMT ) and cell invasion
Sasaki et al., Atherosclerosis 2013
(Atherosclerosis...) :
MMP-2 deficiency
reduced BMP-2 and osteocalcin expression in aortae in Apoe ( -/- ) mice at 30 weeks and 45-60-weeks-old, respectively