Gene interactions and pathways from curated databases and text-mining

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HMGB1 — PCNA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

He et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010 : Compared with the control group, HMGB1 at 10, 50, and 100 ng/mL obviously increased HepG2 cells proliferation, cyclin D1 and PCNA protein and mRNA expression after the treatment for 24 h, respectively ( P < 0.05 )
Feng et al., J Cell Biochem 2012 (Lupus Nephritis) : Inhibition of HMGB1 by a specific short hairpin RNA vector prevented cyclin D1/CDK4/p16 up-regulation and attenuated IFN-? induced MMC cell proliferation and PCNA ( proliferating cell nuclear antigen, PCNA ) expression
Wang et al., Cancer Biol Ther 2012 (Lung Neoplasms) : We observed a MyD88 dependent upregulation of matrix metalloproteinase (MMP) 2, MMP9 and cyclin dependent kinase (CDK) 2 in 95D cells in response to HMGB1