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EIF2AK2 — IGF1
Text-mined interactions from Literome
Chacko et al., Endocrinology 2002
(Brain Neoplasms...) :
Poly ( IC ) activated double stranded RNA activated protein kinase ( PKR ) at 5 min and increased PKR protein levels at 48 and 72 h. Exogenous
IGF-I did not
prevent Poly ( IC ) from activating
PKR , but inhibited the Poly ( IC ) -mediated increase in PKR protein levels
Chacko et al., Endocrinology 2002
(Brain Neoplasms...) :
Both
IGF-I and a blocking antibody against type I interferon ( IFN )
prevented the increase in
PKR levels and the decrease in cell proliferation caused by poly ( IC ) ...
IGF-I prevents IFN from inducing
PKR , thus explaining the ability of IGF-I to reverse the cell cycle blocks and the decreased C6 proliferation caused by poly ( IC )
Russell et al., Cell Signal 2007
:
Angiotensin II induced phosphorylation of
PKR and of the eukaryotic initiation factor-2 ( eIF2 ) on the alpha-subunit, and this was
attenuated by
IGF-I , by induction of the expression of protein phosphatase 1, which dephosphorylates PKR