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LEP — MAPK11
Text-mined interactions from Literome
Takekoshi et al., Endocrinology 2001
:
In contrast,
leptin did not
activate P38
MAPK
Oda et al., Kobe J Med Sci 2001
:
Leptin stimulated phosphorylation and activation of
mitogen activated protein ( MAP ) kinases , and also increased phosphatidylinositol (PI) 3-kinase activity
Machinal-Quélin et al., Am J Physiol Cell Physiol 2002
(MAP Kinase Signaling System) :
Proadipogenic effect of
leptin on rat preadipocytes in vitro :
activation of
MAPK and STAT3 signaling pathways
Bifulco et al., Placenta 2003
(Choriocarcinoma...) :
HG culturing also enhanced
leptin stimulated insulin receptor substrate 1 (IRS1) and
MAPK phosphorylation
Pérez et al., Diabetes 2004
:
However, at elevated concentrations,
leptin impaired insulin stimulated
MAPK activity, glycogen synthase kinase (GSK)3beta phosphorylation, and insulin receptor tyrosine phosphorylation without altering vanadate stimulation
FitzGerald et al., Cell Prolif 2005
(Body Weight...) :
Leptin can
stimulate mitogen activated protein kinase activity in vitro and short-term infusion has been reported to have a proliferative action on the colon in vivo, suggesting a biological link between obesity, physical activity and colon cancer
Mehebik et al., Am J Physiol Cell Physiol 2005
:
Immunoblotting studies have shown that
leptin fails to activate Akt but
increases p42/p44
MAPK phosphorylation, an effect that is prevented by U0126 but not by H-89
Trujillo et al., J Clin Endocrinol Metab 2006
(Obesity) :
The TNF + dex stimulated increase in
leptin was associated with an increase in p38 MAPK activity and was totally
blocked by p38
MAPK inhibitors
Zhao et al., Cell Immunol 2005
(MAP Kinase Signaling System) :
Although gAd partially increased cAMP concentration and PKA activity, it directly reduced
leptin induced ERK1/2 and p38
MAPK phosphorylation thus inhibiting TNF-alpha production
Smith et al., Br J Pharmacol 2006
(Myocardial Reperfusion Injury) :
Western blotting confirmed that
leptin stimulated p44/42
MAPK phosphorylation significantly
Burguera et al., Med Sci Monit 2006
(MAP Kinase Signaling System...) :
Interestingly,
leptin activated
MAPK and the specific MAPK-inhibitor PD98059 blocked DNA synthesis induced by leptin
Cui et al., FASEB J 2006
:
We found
activation of p38
MAPK by
leptin , accompanied by phosphorylation of its downstream effector ATF-1
Sirotkin et al., Comp Biochem Physiol A Mol Integr Physiol 2007
:
Finally,
leptin inhibited expression of
MAPK/ERK1,2 and CDK/p34 and stimulated expression of PKA
Kanda et al., Endocrinology 2008
:
IL-1beta or
leptin individually
induced threonine/tyrosine phosphorylation of p38
MAPK , whereas only leptin induced tyrosine phosphorylation of JAK2, suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB, which is activated by IL-1beta
Carino et al., Int J Cancer 2008
(Adenocarcinoma...) :
Leptin induction of cytokines/receptors generally
involved JAK2 and
MAPK activation, but PI-3K phosphorylation was required for leptin increase of LIF, IL-1/IL-1R tI
Sharma et al., Eur J Pharmacol 2009
:
The aim of the present study was to determine whether nitric oxide and p38
MAPK mediate the stimulation of
leptin by MAPK
Arias-Alvarez et al., Reproduction 2010
:
The aim of this work was to establish whether : 1 ) leptin influences meiotic and cytoplasmic oocyte maturation ; 2 ) STAT3 and
MAPK mediate the effects of
leptin and 3 ) leptin modulates steroid secretion by cumulus-oocyte complexes ( COC ) during in vitro maturation ( IVM )
Akasaka et al., Biochim Biophys Acta 2010
:
Leptin significantly
increased phosphorylation of p38
MAPK , and leptin induced lipid oxidation was abolished by treatment with p38 MAPK siRNA in both types of myotube
Thompson et al., HPB (Oxford) 2011
(Carcinoma, Hepatocellular...) :
Immunoblot analysis demonstrated that
leptin significantly
activated p42/p44-MAPK,
p38-MAPK and STAT3 signalling in a time dependent manner
Garonna et al., PloS one 2011
:
Inhibition of VEGFR2 tyrosine kinase activity reduced
leptin stimulated p38 (
MAPK ) and Akt activation, COX-2 induction, and pro-angiogenic EC responses, and blockade of VEGFR2 or COX-2 activities abolished leptin-driven neo-angiogenesis in a chick chorioallantoic membrane vascularisation assay in vivo
Ge et al., Reproduction 2011
(MAP Kinase Signaling System...) :
Inhibition of p38
MAPK with SB203580 not only
reduced the basal
leptin production but also attenuated the leptin induced production by both hCG and db cAMP
Catalano et al., Am J Pathol 2011
(Breast Neoplasms...) :
In addition, PPAR? ligands inhibited
leptin signaling
mediated by
MAPK/STAT3/Akt phosphorylation and counteracted leptin stimulatory effect on estrogen signaling
Yan et al., Mol Med 2012
:
p38 MAPK was involved in leptin regulation of SREBP-1c expression in cultured HSCs.
Leptin induced activation of p38
MAPK led to the decreases in liver X receptor ( LXR ) -a protein level, activity and its binding to the SREBP-1c promoter, which caused the downregulation of SREBP-1c expression
Sirotkin et al., Animal 2011
:
IGF-I, ghrelin and obestatin, but not
leptin , when given together with PD98059,
increased the accumulation of
MAPK in both immature and mature oocytes
Rajapurohitam et al., Mol Cell Biochem 2012
(Hypertrophy) :
The ability of both angiotensin II- and endothelin-1 to increase
leptin production in cardiomyocytes and the resultant hypertrophic response are
mediated by NF-?B and dependent on p38
MAPK activation
Pijet et al., Cytokine 2013
(MAP Kinase Signaling System) :
Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and
MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were
activated by
leptin , and that STAT3 ( Y ( 705 ) P-STAT3 ) and MEK ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) mediate these effects
Cha et al., BMB Rep 2012
:
We also showed that p38
mitogen activated protein kinase signaling was
involved in
leptin expression induced by HER2
Tanabe et al., Biochem Biophys Res Commun 1997
(Obesity) :
Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of
mitogen activated protein kinase
Yamashita et al., Biochem Biophys Res Commun 1998
:
As the
result of
leptin stimulation, enhanced levels of tyrosine phosphorylation of STAT3 and
MAPK were detected in CHO-OBRb cells ... We report herein the characterization of activities of signal transduction for three types of leptin receptors ( OBRs ) from rats, the OBRa, OBRb, and OBRb with fa mutation ( OBRb-fa ), by measurement of the levels of tyrosine phosphorylation of STAT3 ( signal transducers and activators of transcription 3 ) and
MAPK ( mitogen activated protein kinase ), which are
induced by
leptin stimulation of CHO cells stably expressing the OBR ( CHO-OBRb, CHO-OBRa, or CHO-OBRb-fa cells )
McCowen et al., Endocrinology 1998
:
By contrast,
leptin did not
increase the phosphorylation of Janus kinase proteins,
mitogen activated protein kinase , or STAT1 and -5 despite abundant expression of these signaling molecules in the hypothalamus