◀ Back to TRAF6
IRF7 — TRAF6
Pathways - manually collected, often from reviews:
-
KEGG Toll-like receptor signaling pathway:
TRAF6
→
IRF7
(protein-protein, activation)
-
Reactome Reaction:
IRF7
→
TRAF6
(reaction)
MariƩ et al., Mol Cell Biol 2000*, Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Paz et al., Cell Mol Biol Incl Cyto Enzymol 2006, Ning et al., Mol Cell Biol 2008, Konno et al., PloS one 2009
-
Reactome Reaction:
IRF7
→
TRAF6
(indirect_complex)
Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Ning et al., Mol Cell Biol 2008, Konno et al., PloS one 2009
-
WikiPathways Regulation of toll-like receptor signaling pathway:
TRAF6
→
IRF7
(activation)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
TRAF6
→
IRF7
(activation)
-
WikiPathways Toll-like Receptor Signaling Pathway:
TRAF6
→
IRF7
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
IRF7
—
TRAF6
Kawai et al., Nat Immunol 2004
-
IRef Bind_translation Interaction:
IRF7
—
TRAF6
(coimmunoprecipitation)
Kawai et al., Nat Immunol 2004
-
IRef Biogrid Interaction:
TRAF6
—
IRF7
(physical association, affinity chromatography technology)
Kawai et al., Nat Immunol 2004
-
IRef Biogrid Interaction:
TRAF6
—
IRF7
(physical association, affinity chromatography technology)
Young et al., J Biol Chem 2011*
-
IRef Biogrid Interaction:
TRAF6
—
IRF7
(physical association, affinity chromatography technology)
Hu et al., J Immunol 2011*
-
IRef Hprd Interaction:
TRAF6
—
IRF7
(in vivo)
Kawai et al., Nat Immunol 2004
-
IRef Innatedb Interaction:
IRF7
—
TRAF6
(unknown, -)
Tun-Kyi et al., Nat Immunol 2011*
-
IRef Innatedb Interaction:
IRF7
—
TRAF6
(unknown, -)
Kawai et al., Nat Immunol 2004
-
IRef Innatedb Interaction:
IRF7
—
TRAF6
(unknown, -)
Ning et al., Mol Cell Biol 2008
-
IRef Intact Interaction:
IRF7
—
TRAF6
(physical association, anti bait coimmunoprecipitation)
Tun-Kyi et al., Nat Immunol 2011*
Text-mined interactions from Literome
Kawai et al., Nat Immunol 2004
:
Furthermore, the adaptor molecule
TRAF6 also bound and
activated IRF7 ...
Ubiquitin ligase activity of TRAF6 was
required for
IRF7 activation
Song et al., Proc Natl Acad Sci U S A 2008
:
IRF7 activation by Epstein-Barr virus latent membrane protein 1
requires localization at activation sites and
TRAF6 , but not TRAF2 or TRAF3 ...
IRF7 activation
required TRAF6 and RIP1, but not TRAF2 or TRAF3
Sirois et al., PloS one 2011
:
Knocking down the expression of
TRAF6 in macrophages increased HIV-1 replication and
augmented the expression of
IRF7 but not IRF3
Kitagawa et al., J Virol 2013
:
These results demonstrate that binding of the V protein to
IRF7 , IKKa, and MyD88 is largely indirect and
mediated by endogenous
TRAF6