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CBL — MAPK7
Text-mined interactions from Literome
Rao et al., Proc Natl Acad Sci U S A 2002
:
Finally, analysis of a ZAP-70-deficient T cell line revealed that
Cbl inhibited Lck dependent
mitogen activated protein kinase activation, and an intact Cbl RING finger domain was required for this functional effect
Yan et al., J Cancer Res Clin Oncol 2012
(Breast Neoplasms...) :
Moreover, down-regulation of
Cbl-b by shRNA
led to stronger activation of ERK, JNK and p38
MAPK , more up-regulation of DR4 and DR5, and a stronger synergistic effect of bufalin and TRAIL
Gómez-Martín et al., Arthritis Rheum 2013
(Lupus Erythematosus, Systemic) :
In T cells from lupus patients,
Cbl-b overexpression
led to increased expression of phosphorylated
MAPK , thus indicating the reversibility of anergy resistance