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AGTR2 — TNF
Text-mined interactions from Literome
Wright et al., J Anim Sci 2000
(Inflammation) :
Circulating
TNFalpha was
increased by LPS
at 2 and 4 h after treatment ( P < .001 ), and an apparent ( not statistically significant ) increase in haptoglobin also occurred in challenged animals
Zhai et al., Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 1999
(Burns...) :
Meanwhile,
TNF-alpha mRNA expression significantly
increased in liver, lung, intestine, and kidney
at 2 hours, peaking at 8 hours, and a high level was maintained till 24 hours
Song et al., World J Gastroenterol 2005
(Liver Failure, Acute) :
The integrated OD ( IOD ) levels of TNFalpha receptor 1 protein expressed in the intestine of mice with GalN/LPS and GalN/
TNFalpha induced FHF
at 2 , 6, 9, 12 and 24 h after GalN/LPS and GalN/TNFalpha administration were 169.54+/-52.62/905.79+/-111.84, 11,350.67+/-2 ,133.26/28,160.37+/-4,601.67, 25,781.00 +/-2,277.75/122,352.30+/-49,412.40, 5,241.53+/-3,007.24/49,157.93+/-9,804.88, 7,086.13+/-1,031.15/3,283.45+/-127.67, respectively, compared with those in control groups ( with NS, LPS and GalN administration, respectively )
Hochart et al., Br J Haematol 2006
(Bacterial Infections...) :
Proinflammatory cytokines tumour necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6 and IL-1beta release were subsequently measured by enzyme linked immunosorbent assay at 6 h, and nuclear translocation of the proinflammatory NF-kappaB was assessed
at 2 h. Treatment with pharmacological doses of LMWH and UFH significantly
attenuated LPS induced production of
TNF-alpha , IL-8, IL-6 and IL-1beta as well as NF-kappaB translocation
Mao et al., Neurosci Lett 2006
(Infarction, Middle Cerebral Artery...) :
We found
TNFalpha mRNA expression
increased at 2h and was maintained at high levels until 24h after reperfusion
Okada et al., Am J Pathol 2006
(Anti-Glomerular Basement Membrane Disease...) :
Additional in vitro experiments revealed that
AT2R activation did not
affect nuclear factor-kappaB activation by
tumor necrosis factor-alpha in cultured tubular epithelial cells, although it inhibited ERK phosphorylation, which reduced monocyte chemoattractant protein-1 mRNA levels
Jiang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007
:
AT2 receptors are
involved in
alpha-TNF and IL1 beta secretions in cardiac fibroblasts
Chen et al., World J Gastroenterol 2009
(Pancreatitis) :
After treatment with 5-FU,
TNF-alpha , IL-1, and IL-6 in serum of rats of Group C were
inhibited at 2 and 6 h after operation ( P < 0.05 ), and IL-10, TGF-beta were inhibited at 24 h compared to Group B ( P < 0.05 )
Matavelli et al., Hypertension 2011
(Body Weight...) :
We hypothesized that direct
AT2R stimulation
reduces renal production of the inflammatory cytokines
tumor necrosis factor-a (TNF-a) , interleukin-6 (IL-6), and transforming growth factor-ß1 ( TGF-ß1 ) and enhances the production of nitric oxide ( NO ) and cyclic guanosine 3',5'-monophosphate ( cGMP ) in the clipped kidney of 2-kidney, 1-clip ( 2K1C ) hypertension rat model
Abadir et al., J Interferon Cytokine Res 2011
(Inflammation) :
Further,
AT(2)R activation
reduced TNF-a production by 39 % and STAT3 phosphorylation by 83 %
Martino et al., World journal of gastrointestinal surgery 2012
:
TNF-a and IL-6 serum levels
increased at 2 and 6 h after hepatectomy
Karimian et al., PloS one 2012
(MAP Kinase Signaling System) :
However,
AT-II did not
suppress TNF/Act-D and menadione induced apoptosis
Wood et al., Exp Dermatol 1997
:
Following tape stripping, only the mRNA levels for
TNF-alpha , IL-1 alpha, IL-1 beta and IL-6
increased at 2.5 and 7 h, and returned toward normal levels by 18 h ... In contrast, epidermal
TNF ( p55 ) receptor mRNA levels were
increased by 87 % ( P < 0.01 )
at 2.5 h, returned to control levels at 7 h and were increased by 68 % ( P < 0.03 ) at 18 h after tape stripping
Gao et al., Planta Med 1997
:
T2a-T2d induced human monocytes to produce interleukin-1 (IL-1), interleukin-6 (IL-6), and
tumor necrosis factor (TNF) in vitro