Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
LCK
→
RHOA
(increases, RHOA Activity, LCK Activity)
Evidence: Here we report a novel signaling pathway whereby RhoA can efficiently modulate Stat3 transcriptional activity by inducing its simultaneous tyrosine and serine phosphorylation. Tyrosine phosphorylation is exerted via a member of the Src family of kinases (SrcFK) and JAK2, whereas the JNK pathway mediates serine phosphorylation.