◀ Back to SP1

SP1 — TIMP1

Text-mined interactions from Literome

Aicher et al., Arthritis Rheum 2003 (Arthritis, Rheumatoid) : Since the same DNA sequence was also recognized by the transcription factor Sp-1, our results suggest that the expression of TIMP-1 in synovial fibroblasts may be differentially regulated by Egr-1 and Sp-1
Lee et al., J Cell Biochem 2004 : Sp1 dependent regulation of the tissue inhibitor of metalloproteinases-1 promoter ... In addition, the co-transfection with antisense Sp1 oligonucleotide decreased the promoter activity, suggesting that the transcription of the TIMP-1 promoter is mediated by Sp1 ... The results showed that the TIMP-1 promoter was induced in the presence of cobalt ion and that the promoter activity was regulated by Sp1 as well as HIF-1 ... Therefore, this study suggests that Sp1 is involved in the regulation of the TIMP-1 promoter in the presence of cobalt ion as well as in the basal level transcription
Kwak et al., Mol Cancer Res 2006 (Fibrosarcoma...) : Mithramycin, a specific inhibitor of Sp1 transcription factor , but not curcumin, an inhibitor of activator protein-1, and transfection of Sp1 small interfering RNA significantly inhibited the TGF-beta1 induced expression of TIMP-1