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STS — TNF
Text-mined interactions from Literome
Newman et al., J Steroid Biochem Mol Biol 2000
(Breast Neoplasms) :
TNFalpha plus IL-6
increased STS activity in mock transfected MCF-7 cells and further increased STS activity in transfected MCF-7 cells ... In conjunction with the lack of regulation of STS mRNA it suggest that
TNFalpha and IL-6 may
increase STS activity via a post-translational modification of the enzyme or by increasing substrate availability
Shiohara et al., Biochem Biophys Res Commun 2002
(Inflammation) :
ASC expression was transiently
up-regulated by IL-1alpha, IL-1beta, IFN-alpha, IFN-gamma,
TNFalpha , and LPS
Parsons et al., Oncogene 2006
(Cell Transformation, Neoplastic) :
Induction of
TMS1/ASC by
TNFalpha was blocked by co-expression of a dominant negative IkappaBalpha, small interfering RNA mediated knockdown of RelA/p65, or concurrent treatment with SP600125, indicating a requirement for the nuclear factor-kappaB (NF-kappaB) and jun kinase signaling pathways ... We further show that whereas
TMS1/ASC is not
required for
TNFalpha or TRAIL induced activation of NF-kappaB or caspase-8, it can promote caspase-8 activation independently of death receptor-ligand interactions ... Taken together, these data suggest that
upregulation of
TMS1/ASC by
TNFalpha and subsequent activation of caspase-8 could function to amplify the apoptotic signal induced by death receptors in some cell types, including breast epithelial cells
Franchi et al., Eur J Immunol 2008
(Inflammation) :
The requirement of the Nlrp3 inflammasome was specific for IL-1beta in that secretion of
TNF-alpha was
independent of Nlrp3 or
Asc
Suh et al., Exp Mol Med 2011
(Prostatic Neoplasms) :
Induction of
steroid sulfatase expression by
tumor necrosis factor-a through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells ... To investigate whether tumor necrosis factor (TNF)-a is able to regulate gene transcription of STS, we studied the
effect of
TNF-a on
STS expression in PC-3 human prostate cancer cells ... Treatment with TNF-a resulted in a strong increase in the phosphorylation of Akt on Ser-473 and when cells were treated with phosphatidylinositol (PI) 3-kinase inhibitors such as LY294002 or wortmannin, or Akt inhibitor ( Akt inhibitor IV ),
induction of
STS mRNA expression by
TNF-a was significantly prevented ... Moreover, activation of Akt1 by expressing the constitutively active form of Akt1 increased STS expression whereas dominant negative Akt suppressed
TNF-a mediated
STS induction ... We also found that
TNF-a is able to
increase STS mRNA expression in other human cancer cells such as LNCaP, MDA-MB-231, and MCF-7 as well as PC-3 cells
Ren et al., Mol Med Report 2013
:
Data showed that
ASC overexpression induced by pEGFP-ASC-C2 transfection significantly increased caspase-1 expression and interleukin (IL)-1ß and IL-6 secretion, but did not
affect tumor necrosis factor (TNF)-a secretion
Wu et al., Br J Pharmacol 2013
:
The inhibitory
effects of
STS on
TNF-a and positive feedback signalling of the NF-?B/TNF-a pathways may play important roles in myocardial protection against ischaemia/reperfusion
Wuthrich et al., Transplantation 1993
:
The
TNF-alpha- and PMA stimulated VCAM-1 expression is
inhibited by the PKC and PKA inhibitor
staurosporine (STS)