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MTTP — TNF

Text-mined interactions from Literome

Dieter et al., Mediators Inflamm 1999 : LPS and MTP-PE ( liposome encapsulated N-acetyl-muramyl-L-alanyl-D-isoglutaminyl-L-alanine-2- : [ 1',2'dipalmitoyl -sni-glycero-3- ( hydroxy-phosphoryl-oxyl ) ] etylamide ) induce in liver macrophages a synthesis and release of TNF-alpha , nitric oxide and prostanoids ... Inhibition of NF-kappaB inhibits the LPS- but not the MTP-PE induced release of TNF-alpha , nitric oxide and PGE2 ... Exogenously added PGE2 inhibits the activation of map kinase and TNF-alpha release by LPS, but not by MTP-PE
Tafani et al., Am J Pathol 2000 : These data indicate that induction of the MTP by TNF-alpha causes a release of cytochrome c, caspase-3 activation with PARP cleavage and DNA fragmentation
Dieter et al., J Immunol 1995 : LPS and liposome encapsulated MTP-PE induce liver macrophages cytotoxicity against tumor target cells and a release of TNF-alpha , nitric oxide, and eicosanoids but not a generation of superoxide anions
Landmann et al., Biotherapy 1993 (Carcinoma, Renal Cell...) : MTP-PE caused a marked increase of serum TNFa , IL-1 receptor antagonist (IL-1ra) and IL-6 in week 1, but not thereafter
Asano et al., Cancer Immunol Immunother 1994 : We have already reported that L-MTP-PE induced monocyte mediated tumoricidal activity and up-regulation of the tumor necrosis factor and interleukin-1 (IL-1) in vivo and in vitro
Durham et al., J Surg Res 1998 (Bacteremia...) : Effect of MTP on TNF-alpha in perfused rat liver after bacteremia and ischemia/reperfusion ... MTP increased bioactive TNF-alpha response to EC ( MTP + EC vs EC controls : 685 +/- 255 U/ml vs 250 +/- 180 U/ml, P < 0.02 )