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IL1B — RGS4

Text-mined interactions from Literome

Hu et al., Am J Physiol Cell Physiol 2007 : Upregulation of RGS4 and downregulation of CPI-17 by IL-1beta in muscle strips were corroborated in cultured muscle cells ... These data suggest that IL-1beta upregulates RGS4 expression, resulting in the inhibition of initial contraction and downregulation of CPI-17 expression during sustained contraction in colonic smooth muscle
Hu et al., Biochem J 2008 : RGS4 up-regulation by IL-1beta was blocked by selective inhibitors of IKK2, IkappaBalpha or NF-kappaB activation, by effective siRNA ( small interfering RNA ) of IKK2, and in cells expressing either the kinase-inactive IKK2 mutant ( K44A ) or the phosphorylation-deficient IkappaBalpha mutant ( S32A/S36A ) ... These results suggest that the canonical IKK2/IkappaBalpha pathway of NF-kappaB activation mediates the up-regulation of RGS4 expression in response to IL-1beta and contributes to the inhibitory effect of IL-1beta on acetylcholine stimulated PLC-beta dependent initial contraction in rabbit colonic smooth muscle
Hu et al., Am J Physiol Cell Physiol 2009 : Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway ... Here, we show that the activation of various protein kinases, including ERK1/2, p38 MAPK, and phosphoinositide 3-kinase (PI3K), differentially modulates IL-1beta induced upregulation of RGS4 in rabbit colonic muscle cells ... Pretreatment with PD-98059 ( an ERK inhibitor ) and SB-203580 ( a p38 MAPK inhibitor ) significantly inhibited IL-1beta induced RGS4 expression ... In contrast, LY-294002 ( a PI3K inhibitor ) augmented, whereas GSK3beta inhibitors inhibited, IL-1beta induced RGS4 expression ... These findings suggest that ERK1/2 and p38 MAPK enhance IL-1beta induced upregulation of RGS4 ; the effect of ERK1/2 reflects its ability to promote IKK2 phosphorylation and increase NF-kappaB activity ... The PI3K/Akt/GSK3beta pathway attenuates IL-1beta induced upregulation of RGS4 expression by inhibiting NF-kappaB activation