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CSK — MAPK3
Text-mined interactions from Literome
Daulhac et al., J Biol Chem 1999
:
Expression of
Csk , which inactivates Src-family kinases, totally inhibited gastrin induced Src-like activity detected in anti-Src and anti-Shc precipitates but
diminished by 50 % Shc phosphorylation and
ERK-1 activation
Zagozdzon et al., Cell Signal 2006
(MAP Kinase Signaling System) :
In this work, we compared the
effect of CHK versus
Csk on
MAPK signaling and elucidated the signaling pathway mediated by CHK leading to the activation of Erk1/2 ... Exogenous expression of wild-type CHK, but not
Csk or a dead-kinase mutant of CHK,
resulted in enhanced
Erk1/2 phosphorylation in PC12 cells
Choudhury et al., Cell Signal 2006
:
Inhibition of
c-Src tyrosine kinase blocked PDGF stimulated
MAPK activity and resulted in attenuation of c-fos gene transcription with concomitant prevention of Elk-1 transactivation
Beaulieu et al., Blood 2011
:
Using Meg-01 cells and mouse megakaryocytes, we found that NF?B,
ERK-MAPK , and PI3K/Akt pathways, known downstream pathways of TLRs, are
activated by
Pam3CSK4 , a TLR2-specific ligand