Gene interactions and pathways from curated databases and text-mining

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HSPA5 — MAP2K1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Yacoub et al., Mol Pharmacol 2010 (Ovarian Neoplasms) : MEK1/2 signaling increased expression of the MDA-7/IL-24 and PERK chaperone BiP/78-kDa glucose regulated protein ( GRP78 ), and overexpression of BiP/GRP78 suppressed MDA-7/IL-24 toxicity
Walker et al., Mol Cancer Ther 2010 (Carcinoma...) : MEK1/2 inhibitor and 17AAG treatment increased intracellular Ca ( 2+ ) levels and reduced GRP78/BiP expression in a Ca ( 2+ ) -dependent manner