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JUN — PLD2

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Kim et al., J Biol Chem 2003 : In addition, ARF4 mediated PLD2 activation leads to dramatic activation of the transcription factor activator protein 1 (AP-1) , and, importantly, ARF4 activity is required for EGF induced activation of cellular AP-1
Mollinedo et al., J Immunol 1994 : Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells ... We have examined the possibility that stimulation of phospholipase D ( PLD ) may regulate activation of transcription factor AP-1 in human T cells by transfecting human T lymphocyte Jurkat cells with a plasmid containing an AP-1 enhancer element and a chloramphenicol acetyltransferase reporter gene ... We found a good correlation in the transfected cells between PLD activation and induction of AP-1 enhancer activity under different experimental conditions ... These data indicate that PLD stimulation can activate the transcription factor AP-1 in T lymphocytes, and suggest that the induction of AP-1 enhancer factor activity by PA is mediated via PKC stimulation, either through a direct activating effect of PA or through PA-derived diacylglycerol formation