UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to IL6

IL6 — PIAS3

Pathways - manually collected, often from reviews:

NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3) (modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → PIAS3/MITF complex (PIAS3-MITF) (modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species

Text-mined interactions from Literome

Kamohara et al., Biochem Biophys Res Commun 2000 (Liver Failure, Acute...) : In vitro, IL-6 induced PIAS3 expression in HGF stimulated rat hepatocytes
Kluge et al., Int J Cancer 2009 (Adenocarcinoma...) : EGF and IL-6 stimulation resulted in the association of PIAS3 with STAT3