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CYP3A — IL6
Text-mined interactions from Literome
Ashino et al., Drug Metab Dispos 2004
:
Involvement of
interleukin-6 and tumor necrosis factor alpha in
CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver
Kourylko et al., Drug Metab Dispos 2006
(Inflammation) :
In H ( CONT ), S ( TIIR ) and
IL-6 did not
affect CYP3A6 activity ; however, PDTC reduced CYP3A6 activity by 40 and 80 % after 4 and 24 h of incubation
Ashino et al., Eur J Pharmacol 2007
(Arthritis, Rheumatoid) :
The present study has revealed that
CYP3A11 and metallothionein expressions are
affected by the release of
IL-6 by arthritis and its systemic circulation, and neutralization of IL-6 recovered from the down-regulation of CYP3A11 mRNA and the induction of metallothionein mRNA in arthritic HTLV-I transgenic mice
Tortorici et al., Crit Care Med 2009
(Heart Arrest) :
The
effect of
IL-6 on pregnane X receptor mediated transcription of the rat
CYP3A2 promoter was evaluated via luciferase reporter in HepG2 cells ... Furthermore,
IL-6 attenuated pregnane X receptor mediated transcription of the
CYP3A2 promoter