Carey et al., Mol Cell Biol 2000
(MAP Kinase Signaling System) :
CD28 increases ERK signaling by blocking Rap1 action
Ohnishi et al., J Allergy Clin Immunol 2009
(Inflammation...) :
Pretreatment of effector CD8 ( + ) T cells with U0126 suppressed anti-CD3/anti-CD28 induced ERK1/2 phosphorylation and cytokine production, but did not affect LTB ( 4 ) -induced Ca ( 2+ ) mobilization or chemotaxis
Pastorino et al., FASEB J 2010
:
However, PEA-15 deficient T cells had increased CD3/CD28 induced nuclear translocation of ERK and increased activation of IL-2 transcription and secretion in comparison to control wild-type littermates