◀ Back to IGF2
IGF2 — PDE3B
Text-mined interactions from Literome
Ahmad et al., J Immunol 2000
:
In F/V cells,
IGF-1 increased PKB,
PDE3B , and PDE4 activities approximately 2-fold ... In F/B cells,
IGF-1 , in a wortmannin-sensitive manner,
increased PKB activity approximately 10-fold and
PDE3B phosphorylation and activity ( approximately 4-fold ), but increased PDE4 to the same extent as in F/V cells
Ahmad et al., Cell Signal 2000
:
Furthermore,
IGF-1 dependent stimulation of p42/p44 MAPK and
PDE3B was abolished in serum deprived cells and this was associated with apoptosis ... Therefore,
IGF-1 dependent regulation of
PDE3B may be linked to cell survival through PI3K and not p42/p44 MAPK
Sadler et al., Mol Endocrinol 1991
:
This pharmacological evidence demonstrates a necessary
role for
PDE III in insulin-,
IGF-I- , and p21ras induced meiotic cell division in Xenopus laevis oocytes