◀ Back to RAC1

NF2 — RAC1

Text-mined interactions from Literome

Wei et al., J Virol 2005 : Merlin , a cellular substrate of PAK2, is homologous to the ezrin-radixin-moesin family and plays a critical role in Rac signaling
Nakai et al., J Neurosci 2006 : NF2 is involved in suppression of Rac signaling, and cultured schwannoma cells contain elevated, GTP bound, active Rac
Flaiz et al., J Neuropathol Exp Neurol 2007 (Neurilemmoma) : We suggest that the Merlin deficiency in human primary schwannoma cells leads to a random, nonlocalized activation of Rac1 and Cdc42, inducing many actin-rich protrusion zones, not only at the leading edge but also all around the cell periphery
Huang et al., Oncogene 2008 (Neurilemmoma...) : Consistently, VprBP depletion abolished the in vivo interaction of Merlin and Roc1-Cullin4A-DDB1, which resulted in Merlin stabilization and inhibited ERK and Rac activation
Manchanda et al., Oncogene 2013 (Neurilemmoma) : Rac1 is required for Prkar1a mediated Nf2 suppression in Schwann cell tumors ... These in vivo data indicate that activation of Rac1 is responsible for suppression of Nf2 protein production ; deficiency of Nf2 in Schwann cells leads to loss of cellular growth control and tumor formation ... Although in vitro evidence has shown that loss of Nf2 activates Rac1 , our data indicate that signaling between Nf2 and Rac1 occurs in a bidirectional fashion, and these interactions are modulated by PKA