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CCND1 — EGF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCND1 → EGF (increases)
  Evidence: Levels of cyclin D1 protein were elevated following 3 h arsenic and EGF (Fig. 2A, row 1 CCND1). The positive control, EGF also induced a large increase in cyclin D1 levels.

Text-mined interactions from Literome

Thomas et al., J Cell Physiol 1999 (Breast Neoplasms) : However, EGF had no significant effect on the expression of cyclin D1 or cyclin E
Tong et al., Oncol Res 1999 (Colonic Neoplasms) : In addition, 1alpha,25- ( OH ) 2D3 significantly reduced basal and EGF stimulated expression of cyclin D1 at the mRNA and protein level in primary cultures as well as in the Caco-2 cell line
Kim et al., J Biol Chem 1999 : We conclude that in 3T3-F442A cells, 1 ) the GH-induced decrease in ErbB-2 tyrosine phosphorylation correlates with MEK1/mitogen activated protein kinase activity and 2 ) GH antagonizes EGF induced DNA synthesis and cyclin D1 expression in a pattern consistent with its alteration in ErbB-2 phosphorylation status
Dufourny et al., J Endocrinol 2000 (Breast Neoplasms) : Since transcriptional activation of the cyclin D1 promoter by EGF , E2 and TPA is independent of PI3-K activity, these findings suggest a post-transcriptional role for PI3-K in the regulation of cyclin D1 expression
Yan et al., J Cell Physiol 2000 : Perturbation of EGF activated MEK1 and PKB signal pathways by TGF-beta1 correlates with perturbation of EGF induced cyclin D1 and DNA synthesis by TGF-beta1 in C3H 10T1/2 cells ... In mouse C3H 10T1/2 cells, we previously reported that TGF-beta1 first delays and later potentiates EGF induced DNA synthesis corresponding to an inhibition of EGF induced cyclin D1 expression at t = 13 h ... We report here that in accord with DNA synthesis kinetics, TGF-beta1 initially suppresses EGF induced cyclin D1 expression then later releases the inhibition
Osada et al., Jpn J Cancer Res 2000 (Pancreatic Neoplasms) : EGF induced cell proliferation through ERK phosphorylation, since U0126, which is an inhibitor of ERK phosphorylation, abrogated the increase of cyclin D1 by EGF
Moriuchi et al., Biochem Biophys Res Commun 2001 (MAP Kinase Signaling System) : Treatment with a combination of HGF and EGF, in comparison with that of either HGF or EGF, induced tyrosine phosphorylation of both c-Met and EGF receptor (EGFR) independently and additively stimulated MAPK activity and cyclin D1 expression, resulting in additive stimulation of DNA synthesis
Osada et al., Cancer 2001 (Stomach Neoplasms) : Epidermal growth factor (EGF) or hepatocyte growth factor (HGF) stimulated increase of cyclin D1 protein after 12 hours and increased DNA content after 3 days in culture
Zhao et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Moreover, betaVLDL plus EGF synergistically induce cyclin D1 expression and down-regulate p27 ( KIP1 ) expression
Poch et al., Pancreas 2001 (Pancreatic Neoplasms) : These results demonstrate that cyclin D1 overexpression in the tumor cells of pancreatic carcinoma tissue is at least partly dependent on the mitogenic effects of EGF signaling through the EGFR
Saikawa et al., Jpn J Cancer Res 2001 (Stomach Neoplasms) : In conclusion, EGF stimulated MKN-74 cell proliferation was inhibited by AS/D1, which could overcome EGF induced cyclin D1 over-expression
Lonardo et al., Clin Cancer Res 2002 (Cell Transformation, Neoplastic...) : This treatment reduced EGF dependent mitogenesis as well as EGFR associated phosphotyrosine levels and cyclin D1 expression
Liberto et al., Oncogene 2002 : In addition, C3 blocked EGF stimulated cyclin D1 promoter activity whereas V14RhoA induced the cyclin D1 promoter and cooperated with V12Ras in cyclin D1 induction
Siu et al., Prostate 2002 (Prostatic Neoplasms) : Melatonin and 2-iodomelatonin ( a melatonin receptor agonist ) attenuated EGF stimulated increases in LNCaP cell proliferation and cyclin D1 levels ... Androgen-sensitive prostate cancer cell proliferation may be modulated by opposite changes in cyclin D1 levels induced by activated MT(1) and EGF receptors
Schwabe et al., Hepatology 2003 : In epidermal growth factor (EGF) treated primary cultures of rat hepatocytes, SP600125 decreased ( 3 ) H-thymidine uptake, cyclin D1 mRNA and protein expression, and inhibited the EGF induced transcription of a cyclin D1 promoter-driven reporter gene
Thevananther et al., Hepatology 2004 : Extracellular ATP as low as 10 nM was sufficient to potentiate EGF induced cyclin D1 expression
Barbieri et al., Eur J Cell Biol 2004 : Expression of Rab5 : S34N and Rin1 also block EGF induction of cyclin D1 transcription ... In contrast, expression of Rin1 : delta, a natural splice variant of Rin1 lacking 47 amino acids in the Vps9p domain or Rab5, increase both activation of Raf-Erk1/2- and cyclin D1 transcription in response to EGF
Petty et al., Clin Cancer Res 2004 (Gastrointestinal Neoplasms...) : We reported previously that epidermal growth factor stimulation markedly increased cyclin D1 protein expression in human bronchial epithelial ( HBE ) cells, and this was opposed by chemoprevention with all-trans-retinoic acid
Velarde et al., J Endocrinol 2005 (Carcinoma...) : We have further shown that EGF promotion of cell proliferation, but not induction of cyclin D1 gene expression, involves SLPI
Häussler et al., American journal of physiology. Renal physiology 2005 : In addition, EGF stimulated cyclin D1 promoter activity as well as cyclin D1 expression ... Moreover, inhibition of NF-kappaB caused a pronounced reduction of EGF induced cyclin D1 promoter activity ... Furthermore, both EGF mediated NF-kappaB activation and cyclin D1 expression were inhibited by coexpression of super IkappaB
Heo et al., Am J Physiol Cell Physiol 2006 (MAP Kinase Signaling System) : Finally, inhibition of EGFR tyrosine kinase, PKC, Ca2+ channels, or p44/42 MAPKs attenuated EGF stimulated cyclin D1 , cyclin E, cyclin dependent kinase (CDK)2, and CDK4, respectively
Wang et al., Zhonghua Wai Ke Za Zhi 2005 (Breast Neoplasms) : EGF could remarkably enhance cyclin D(1) expression about 83 % more in EGF group than that in control group and proliferation index from 0.22 to 0.31 ( P < 0.01 )
Lee et al., J Cell Biochem 2006 : Moreover, EGF increased the CDK-2, CDK-4, cyclin D1 , and cyclin E expression levels but decreased the p21 and p27 expression levels
Paternot et al., Mol Endocrinol 2006 : In primary cultures of normal human thyrocytes, EGF + serum increased cyclin D1 and p21 accumulation, and it stimulated the assembly and activity of cyclin D1-CDK4-p21 complexes
Dajani et al., J Cell Physiol 2008 (Carcinoma, Hepatocellular...) : Treatment of the hepatocytes with PGE2 at 3 h after plating amplified the stimulatory effect on DNA synthesis of EGF administered at 24 h and advanced and augmented the cyclin D1 expression in response to EGF in hepatocytes
Cao et al., Science signaling 2009 : In addition, ablation of Galpha ( i1 ) and Galpha ( i3 ) largely inhibited EGF induced cell growth, migration, and survival and the accumulation of cyclin D1
Nakashima et al., Int J Oncol 2010 (Colonic Neoplasms...) : Moreover, whereas EGF increased the phosphorylation of retinoblastoma tumor suppressor protein as well as cyclin D1 protein expression level, pretreatment with Y27632 accelerated them
Sen et al., J Biol Chem 2010 (MAP Kinase Signaling System...) : Importantly, Erk mediated serine phosphorylation of paxillin is also required for DHT induced prostate-specific antigen mRNA expression in LnCAP cells as well as EGF induced cyclin D1 mRNA expression in PC3 cells, suggesting that paxillin may regulate prostate cancer proliferation by serving as a liaison between extra-nuclear kinase signaling and intra-nuclear transcriptional signals
Lee et al., Cancer prevention research (Philadelphia, Pa.) 2011 (Hyperplasia...) : Furthermore, a promoter analysis revealed that the activator protein-1 transcription factor regulates EGF induced cyclin D1 overexpression ... Activator protein-1 depletion by using siRNA targeting its c-Jun component completely abrogated EGF induced cyclin D1 expression
Zhang et al., Toxicol Appl Pharmacol 2012 : We found that SAHA treatment resulted in the dramatic inhibition of EGF induced cell transformation, cyclin D1 protein expression and induction of G0/G1 growth arrest ... Moreover, SAHA inhibited EGF induced cyclin d1 mRNA level, whereas it did not show any inhibitory effect on cyclin D1 promoter-driven luciferase reporter activity under the same experimental conditions, suggesting that SAHA may decrease cyclin D1 mRNA stability
Yang et al., Cell 2012 (Astrocytoma...) : PKM2 dependent histone H3 modifications are instrumental in EGF induced expression of cyclin D1 and c-Myc, tumor cell proliferation, cell-cycle progression, and brain tumorigenesis
Zhang et al., PloS one 2012 (Breast Neoplasms) : EGF at 10 ng/ml also induced phosphorylation of the MAPK/ERK and activated cyclin D1 promoter activity through the Src/EGFR/STAT5 pathways but not at a higher concentration ( 500 ng/ml )
Ravitz et al., J Cell Physiol 1996 : Differential regulation of p27 and cyclin D1 by TGF-beta and EGF in C3H 10T1/2 mouse fibroblasts ... Also in contrast with TGF-beta, EGF causes a strong upregulation of cyclin D1 , while neither growth factor affects cdk4 protein levels ... In support of this hypothesis, TGF-beta prevents EGF induced upregulation of cyclin D1 levels, while TGF-beta is still able to induce p27 down-regulation even in the presence of EGF
Perry et al., Prostate 1998 (Prostatic Neoplasms) : Western analyses demonstrated that EGF stimulated cyclin D1 protein expression 4-fold over 12 hr. Northern analyses showed a 4-fold increase in mRNA expression, peaking within 4 hr of EGF stimulation ... In addition, we demonstrated the involvement of the protein kinase C pathway in mediating the EGF induction of cyclin D1