Gene interactions and pathways from curated databases and text-mining

◀ Back to TP53

NFYC — TP53

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Yun et al., J Biol Chem 1999 : These results suggest that p53 negatively regulates cdc2 transcription and that the NF-Y transcription factor is required for the p53 mediated regulation
Joshi et al., Mol Pharmacol 2003 : The expression of mutant p53 does not affect the binding of NF-Y
Yun et al., Cancer research and treatment : official journal of Korean Cancer Association 2006 : p53 is essential to prevent immature escaping from cell cycle G2 checkpoint arrest through p21 mediated cdk2 inactivation, and this leads to inhibition of cdk2 dependent NF-Y phosphorylation and NF-Y dependent transcription of the cell cycle G2-regulatory genes, including cdc2 and cyclin B
Gurtner et al., Cancer Res 2010 : Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation
Tue et al., Gene 2011 : NF-Y transcriptionally regulates the Drosophila p53 gene
Park et al., Cardiovasc Res 2011 : Anthracycline down-regulation of GATA4 is mediated by the inhibition of Gata4 gene transcription via a novel mechanism that involves the p53 dependent inhibition of CBF/NF-Y binding to the CCAAT box within the Gata4 promoter