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CHEK2 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
TP53
—
CHEK2
(experimental interaction detection)
Bjørling-Poulsen et al., Oncogene 2005*
-
IRef Biogrid Interaction:
CHEK2
—
TP53
(direct interaction, enzymatic study)
Adams et al., EMBO Rep 2008*
-
IRef Biogrid Interaction:
CHEK2
—
TP53
(direct interaction, enzymatic study)
Hirao et al., Science 2000*
-
IRef Biogrid Interaction:
CHEK2
—
TP53
(direct interaction, enzymatic study)
Bjørling-Poulsen et al., FEBS Lett 2005*
-
IRef Biogrid Interaction:
CHEK2
—
TP53
(direct interaction, enzymatic study)
Shieh et al., Genes Dev 2000*
-
IRef Biogrid Interaction:
CHEK2
—
TP53
(physical association, affinity chromatography technology)
Louria-Hayon et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
TP53
—
CHEK2
(in vitro)
Bruno et al., Cancer Cell 2006*
-
IRef Intact Interaction:
CHEK2
—
TP53
(phosphorylation reaction, protein kinase assay)
Adams et al., EMBO Rep 2008*
-
IRef Intact Interaction:
CHEK2
—
TP53
(phosphorylation reaction, experimental interaction detection)
Lee et al., Nature 2000*
-
IRef Intact Interaction:
CHEK2
—
TP53
(phosphorylation reaction, experimental interaction detection)
Bjørling-Poulsen et al., FEBS Lett 2005*
Text-mined interactions from Literome
Tominaga et al., J Biol Chem 1999
:
In addition, transfection of normal human fibroblasts with SV40 T antigen or human papilloma viruses E6 or E7 causes a marked induction of hCds1 mRNA, and the introduction of functional p53 into SV40 T antigen- and E6-, but not E7-, transfected cells decreases the hCds1 level, suggesting that
p53 negatively
regulates the expression of
hCds1
Dong et al., Am J Hum Genet 2003
(Prostatic Neoplasms) :
In this study, we analyzed
CHEK2 , the upstream
regulator of
p53 in the DNA-damage signaling pathway, in several groups of patients with prostate cancer
Ahn et al., J Biol Chem 2003
(Colonic Neoplasms) :
Questioning the
role of
checkpoint kinase 2 in the
p53 DNA damage response
Chin et al., Exp Mol Pathol 2003
:
Tissue-specific
regulation of
checkpoint kinase 2 expression by
p53
Spurlock et al., Arthritis Rheum 2012
(Arthritis, Rheumatoid...) :
In tissue culture, MTX
induced expression of both
p53 and p21 by JNK-2- and JNK-1 dependent mechanisms, respectively, while
CHEK2 and RANGAP1 were not induced by MTX