◀ Back to JUN

JUN — PTGS2

Text-mined interactions from Literome

Wadleigh et al., Biochem Biophys Res Commun 1999 : Induction of wild-type COX-2 reporter gene expression in MC3T3-E1 cells by all these agents involves signaling through the MEKK/JNK pathway and activation of both c-Jun and the C/EBP family of transcription factors
Matsuoka et al., J Cereb Blood Flow Metab 1999 (Ischemic Attack, Transient) : These results suggest the following : ( 1 ) c-Jun phosphorylation was associated with ischemia/reperfusion induced neuronal apoptosis ; ( 2 ) HO-1 and COX-2 were induced in CA1 pyramidal neurons, which undergo cell death ; and ( 3 ) most CA1 pyramidal neurons expressed HO-1, COX-2, or both, which strongly suggests that these are candidates for neuron killers
Subbaramaiah et al., J Biol Chem 2000 : A dominant negative form of c-Jun inhibited the activation of the COX-2 promoter by MIAs
Allport et al., Mol Hum Reprod 2000 : NF-kappaB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line ( WISH )
Ogasawara et al., J Biol Chem 2001 : These data suggest that C/EBP beta, AP-1 , and CREB play crucial roles in the shear stress induced cox-2 expression in osteoblasts
Zhang et al., Neoplasia (New York, N.Y.) 2000 : Expression of a dominant negative c-Jun N-terminal kinase (JNK) had no effect on COX-2 mRNA stability in cells treated with CD or ceramide
Kulkarni et al., Clin Cancer Res 2001 (Adenocarcinoma...) : Moreover, overexpressing dominant negative forms of extracellular signal regulated kinase 1, c-Jun NH2-terminal kinase, p38, and c-Jun blocked EGF mediated induction of COX-2 promoter activity
Guo et al., J Biol Chem 2001 (Cell Transformation, Neoplastic...) : Bombesin stimulation of COX-2 expression requires an increase in [ Ca ( 2+ ) ] ( i ), activation of extracellular signal regulated kinase ( ERK ) -1 and -2 and p38 ( MAPK ), and increased activation and expression of the transcription factors Elk-1, ATF-2, c-Fos, and c-Jun
Hsu et al., J Immunol 2001 : In conclusion, we suggest that ceramide inhibition of LPS mediated induction of inducible NO synthase and cyclooxygenase-2 is due to reduction of the activation of NF-kappaB and AP-1 , which might result from ceramide 's inhibition of LPS stimulated IkappaB kinase, p38 mitogen activated protein kinase, and protein kinase C
Subbaramaiah et al., Cancer Res 2002 : The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element ( CRE ) of the COX-2 promoter ... Thus, RA acted by a receptor dependent mechanism to limit the amount of CBP/p300 that was available for AP-1 mediated induction of COX-2 ... By contrast, carnosol inhibited the induction of COX-2 by blocking PKC signaling and thereby the binding of AP-1 to the CRE of the COX-2 promoter
Liu et al., J Biol Chem 2003 (Cell Transformation, Neoplastic) : In JB6, Cox-2 ( -/- ), or wild-type Cox-2 ( +/+ ) cells, both NS-398 and piroxicam inhibited UVB induced phosphorylation of c-Jun NH ( 2 ) -terminal kinases, the kinases that activate the AP-1/c-Jun complex
Lee et al., Br J Pharmacol 2003 : The effects of sauchinone on the inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase 2 (COX-2) gene expression and on the activation of transcription factors, nuclear factor-kappaB (NF-kappaB), CCAAT/enhancer binding protein (C/EBP), activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects
Chun et al., Carcinogenesis 2004 : Celecoxib inhibits phorbol ester induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin
Mahns et al., Photochem Photobiol Sci 2004 : COX-2 induction by simulated solar light is attenuated in the presence of inhibitors of p38 ( MAPK ) or of c-Jun-N-terminal kinases (JNK) , whereas COX-2 induction by UVA is blocked only by inhibition of JNK
Chen et al., Biochim Biophys Acta 2004 (Carcinoma, Squamous Cell...) : Essential role of c-Jun induction and coactivator p300 in epidermal growth factor induced gene expression of cyclooxygenase-2 in human epidermoid carcinoma A431 cells ... All together, these results indicated that the EGF induced expression of COX-2 in A431 cells was mediated through the Ras-ERK/JNK signaling pathway, and subsequent induction of c-Jun following MAPK activation, in cooperation with coactivator p300, was required for the EGF response
Grau et al., Cancer Res 2004 (Colonic Neoplasms) : This cyclopentenone was able to inhibit activator protein1 (AP-1) dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate ( PMA ) or c-Jun overexpression
Chen et al., Mol Pharmacol 2005 : Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun ... We found previously that c-Jun induction plays a crucial role in epidermal growth factor (EGF) induced gene expression of COX-2 ... In this study, the functional role of c-Jun in EGF induced transcriptional activation of COX-2 in A431 cells was investigated ... These results indicated that c-Jun N-terminal phosphorylation was not required for EGF induced expression of COX-2 ... c-Jun , which could recruit other transcription factors such as c-Fos, was required for EGF induced expression of COX-2 in A431 cells
Hwang et al., J Biol Chem 2005 : c-Jun/activator protein-1 mediates interleukin-1beta induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes ... Here, we investigated the role of c-Jun and activator protein-1 (AP-1) in IL-1beta induced dedifferentiation and cyclooxygenase (COX)-2 expression in primary cultured chondrocytes ... Interestingly, modulation of c-Jun expression did not affect IL-1beta induced COX-2 expression ... Further experiments revealed that c-Jun phosphorylation was mediated by c-Jun N-terminal kinase and was required for IL-1beta induced dedifferentiation but not COX-2 expression
Yamaguchi et al., J Biol Chem 2005 : We investigated whether HDAC inhibitors blocked AP-1 mediated activation of COX-2 transcription ... Trichostatin A and suberoylanilide hydroxamic acid, two structurally related inhibitors of HDAC activity, blocked AP-1 mediated induction of COX-2 expression and prostaglandin E2 biosynthesis
Cho et al., Exp Mol Med 2005 : Curcumin inhibits the expression of COX-2 in UVB irradiated human keratinocytes ( HaCaT ) by inhibiting activation of AP-1 : p38 MAP kinase and JNK as potential upstream targets
Li et al., Free Radic Biol Med 2005 : These results suggest that excessive NO production during inflammation induces apoptosis in PC12 cells through AP-1 mediated upregulation of COX-2 expression
Uenoyama et al., Oncogene 2006 (Anoxia...) : Furthermore, COX-2 expression was also reduced by the inhibition of transcription factor AP-1
Degner et al., J Nutr 2006 (Breast Neoplasms) : Collectively, these results suggest that CLA represses AP-1 mediated activation of COX-2 transcription
Woo et al., Biochem Biophys Res Commun 2006 : Proteasome inhibitor induced cyclooxygenase-2 expression in Raw264.7 cells is potentiated by inhibition of c-Jun N-terminal kinase activation ... The p38 MAPK inhibitor ( SB 203580 ) prevented MG132 induced COX-2 expression, whereas c-Jun N-terminal kinase (JNK) inhibitor ( SP 600125 ) and MAPK kinase 4 ( MKK4 ) -DN ( dominant negative mutant ) and MKK7-DN significantly enhanced COX-2 expression
Tang et al., Mol Cancer Ther 2006 (Breast Neoplasms) : The induction of COX-2 accumulation by resveratrol is mitogen activated protein kinase ( MAPK ; extracellular signal regulated kinase 1/2 ) - and activator protein 1- dependent
Zhang et al., Carcinogenesis 2007 : Further investigation revealed that JNK1 mediated the nickel induced COX-2 expression in a c-Jun/AP-1 dependent manner
Kang et al., J Immunol 2006 (Disease Models, Animal...) : In support of this concept, we found, using inhibitors of Jun kinase and NF-kappaB p50 nuclear localization, that COX-2 gene transcription was completely dependent on phospho-c-Jun plus p50 at 6 h after LPS treatment but was only partially dependent on the combination of these factors at later treatment times
Lee et al., Carcinogenesis 2007 (MAP Kinase Signaling System) : Humulone inhibits phorbol ester induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1 : IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets
Park et al., Ann N Y Acad Sci 2007 : KG-135 inhibits COX-2 expression by blocking the activation of JNK and AP-1 in phorbol ester stimulated human breast epithelial cells
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Wang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007 (Disease Models, Animal...) : [ Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease ] ... P-c-Jun expression may play an important role in mediating COX-2 expression in the SN in the MPTP model of subacute PD, and inhibiting p-c-Jun activity may provide neuroprotection to the mouse model
Kim et al., Carcinogenesis 2008 (Breast Neoplasms) : 15d-PGJ ( 2 ) -induced COX-2 expression was mediated by activation of Akt and subsequently activator protein-1 (AP-1)
Healy et al., Am J Physiol Cell Physiol 2008 : Deletion and mutation analyses of the human cox-2 promoter reveal that the CCAAT/enhancer binding protein (C/EBP) and activator protein-1 (AP-1) predominantly contribute to the shear induced cox-2 promoter activity ... Individual gene knockdown experiments demonstrate the direct regulation of C/EBPbeta expression by c-Jun, and the critical roles of both c-Jun and C/EBPbeta in shear induced COX-2 synthesis
Subramaniam et al., Gastroenterology 2008 (Adenocarcinoma...) : Further studies showed that COX-2 gene transcription is regulated by activator protein-1
Hsieh et al., Biochim Biophys Acta 2008 : Moreover, thrombin stimulated activation of NF-kappaB, AP-1, and COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR, MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Scheckel et al., J Nutr 2008 : Rosmarinic acid antagonizes activator protein-1 dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines
Kim et al., Carcinogenesis 2009 (Uterine Cervical Neoplasms) : Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein
Cho et al., Dig Dis Sci 2010 (Adenocarcinoma...) : Involvement of Ras and AP-1 in Helicobacter pylori induced expression of COX-2 and iNOS in gastric epithelial AGS cells ... We investigated whether H. pylori in a Korean isolate ( HP99 ), a cagA ( + ), vacA ( + ) strain, induces the expression of c-Fos and c-Jun for AP-1 activation to induce COX-2 and iNOS and whether HP99 induced expressions of COX-2 and iNOS are mediated by Ras and AP-1 , determined by the expressions of c-Fos and c-Jun, in gastric epithelial AGS cells, using transfection with mutant genes for Ras ( ras N-17 ) and c-Jun ( TAM-67 )
Passos et al., Am J Pathol 2009 (Inflammation) : MIP-1alpha ( -/- ) and CCR5 ( -/- ) mice displayed reduced astrocytosis and microgliosis in the hippocampus after Abeta ( 1-40 ) administration that was associated with decreased expression of cyclooxygenase-2 and inducible nitric oxide synthase, as well as reduced activation of nuclear factor-kappaB, activator protein-1 and cyclic AMP response element binding protein
Han et al., Food Chem Toxicol 2010 : Thus, DHCT is an effective agent to attenuate COX-2 production mediated by the transcription factors C/EBP and AP-1 , and these results enhance our understanding of the anti-inflammatory and anti-cancer properties by DHCT
Camalier et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Cell Transformation, Neoplastic...) : Supplementation of medium with phosphate increased anchorage independent transformation and proliferation of BALB/c mouse JB6 epidermal cells, activation of N-ras, ERK1/2, and activator protein-1 , and increased gene expression of Fra-1, COX-2 , and osteopontin in a dose dependent manner
Shrotriya et al., Cancer Res 2010 (Skin Neoplasms) : Diallyl trisulfide inhibits phorbol ester induced tumor promotion, activation of AP-1 , and expression of COX-2 in mouse skin by blocking JNK and Akt signaling ... Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA treated mouse skin
Lu et al., J Cell Biochem 2010 (Glioma) : One mechanism underlying bradykinin directed migration is transcriptional up-regulation of COX-2 and activation of the B1R receptor, PI-3 kinase, AKT, c-Jun , and AP-1 pathways
Lim et al., Biochem Pharmacol 2011 : By using PP2, a pharmacological inhibitor for SFKs, we showed that Fyn kinase regulates B [ a ] PDE induced COX-2 expression by activating MAPKs, AP-1 and NF-?B
Chen et al., Cell Microbiol 2011 : Inhibition of NF-?B and AP-1 activations blocked the J96-1 induced COX-2 promoter activity and expression
Tsai et al., J Dermatol Sci 2013 (Gram-Positive Bacterial Infections...) : ROS dependent stimulation of ERK, JNK, NF-?B, and AP-1 activation contributes to P. acnes induced iNOS/NO and COX-2/PGE ( 2 ) in macrophages, and chemicals such as hispolon possessing ability to block iNOS/NO and COX-2/PGE ( 2 ) production reserve potential to be further developed for treatment of the early phase of inflammation elicited by P. acnes
Zhang et al., J Biol Chem 1998 : Because other activators of PKC and AP-1 induce cyclooxygenase-2 (COX-2) , we determined the effects of bile acids on the expression of COX-2 in human esophageal adenocarcinoma cells
Subbaramaiah et al., J Biol Chem 1998 : Thus, in response to ceramide, increased MAPK signaling activates c-Jun , which, in turn, induces COX-2 gene expression via the cAMP response element in the COX-2 promoter
von Knethen et al., Mol Biol Cell 1999 : Whereas cytokine mediated Cox-2 induction relies on NF-kappaB activation, a low-level NO-elicited Cox-2 response required activation of both NF-kappaB and AP-1