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GJA1 — JUN

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: Fra2/JUN complex (FOSL2-JUN) → Connexin 43 (GJA1) (transcription, activates) Echetebu et al., Mol Hum Reprod 1999*, Mitchell et al., Endocrinology 2005*
  Evidence: reporter gene, physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS complex (FOS-JUN) → Connexin 43 (GJA1) (transcription, activates) Mitchell et al., Cell communication & adhesion 2001*, Mitchell et al., Endocrinology 2005*
  Evidence: reporter gene
• WikiPathways Myometrial Relaxation and Contraction Pathways: Complex of FOS-JUN → OXTR/GJA1 (mim-transcription-translation)

Text-mined interactions from Literome

Andersen et al., Environ Health Perspect 2000 (Leiomyoma...) : However, estrogen did not induce myometrial cx43 gene transcription in vitro ; instead, it inhibited AP-1 induction of cx43 expression ... Results from an examination of pregnancy myometrial tissue support the concept that AP-1 activity is involved in the induction of myometrial cx43 expression at term and that suppression of ER-beta expression is needed for this induction
Petrich et al., Circ Res 2002 (Heart Failure) : c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes
Ursitti et al., J Mol Cell Cardiol 2007 : Decreases in the expression of connexin 43 and the integrity of gap junctions in cardiac muscle, induced by the constitutive activation of the c-Jun N-terminal kinase (JNK) signaling pathway, have been linked to conduction defects and sudden cardiac failure in mice [ Petrich BG, Gong X, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang Y. c-Jun N-terminal kinase activation mediates downregulation of connexin 43 in cardiomyocytes
Yan et al., Cardiovasc Res 2013 (Arrhythmias, Cardiac...) : c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias