Takaoka et al., Nature 2003
(Cell Transformation, Neoplastic...) :
Here we show that transcription of the p53 gene is induced by IFN-alpha/beta , accompanied by an increase in p53 protein level ... IFN-alpha/beta signalling itself does not activate p53 ; rather, it contributes to boosting p53 responses to stress signals ... We show examples in which p53 gene induction by IFN-alpha/beta contributes to tumour suppression
Natsume et al., Cancer Chemother Pharmacol 2008
(Eye Neoplasms...) :
In this study, ( 1 ) we explored the synergistic effect of IFN-beta and TMZ in the animal model, and ( 2 ) clarified the role of IFN-beta induced TP53 in the human MGMT promoter
Zhang et al., Immunology 2009
:
The relationship between the p53 signal pathway and the response of human peripheral blood mononuclear cells ( PBMC ) to interferon (IFN)-beta has hitherto not been examined
Jiang et al., Oncogene 1995
(Melanoma...) :
Induction of growth arrest and terminal differentiation in H0-1 human melanoma cells by IFN-beta + MEZ results in a temporal decrease in wild-type p53 protein levels with a corresponding increase in p21 levels