Huang et al., Proc Natl Acad Sci U S A 2001
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In conclusion, these data indicate that insulin signaling inhibits Rab5 activity and the interaction of dynein with microtubules in a PI3-kinase dependent manner, and that these effects may inhibit the rate of GLUT4 internalization
Lodhi et al., Mol Biol Cell 2008
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Here, we report that insulin stimulated PI(3)P production requires the activation of Rab5 , a small GTPase that plays a critical role in phosphoinositide synthesis and turnover
Bridges et al., J Biol Chem 2012
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Additionally, regulation of PI(3)P synthesis by Rab5 and Vps21 is essential for TORC1 function in both contexts