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JARID2 — RBBP4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
JARID2
→
RBBP4
(indirect_complex)
-
Reactome Reaction:
JARID2
→
RBBP4
(reaction)
Cao et al., Science 2002, Kuzmichev et al., Genes Dev 2002, Kuzmichev et al., Mol Cell 2004, Martin et al., J Biol Chem 2006, Margueron et al., Mol Cell 2008, McCabe et al., Proc Natl Acad Sci U S A 2012, Swalm et al., Biochem J 2013
-
WikiPathways Interactome of polycomb repressive complex 2 (PRC2) :
RBBP4
→
JARID2
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Shen et al., Cell 2009
:
In vitro
JMJ inhibits
PRC2 methyltransferase activity, consistent with increased H3K27me3 marks at PRC2 targets in Jmj ( -/- ) ESCs ... Paradoxically,
JMJ is
required for efficient binding of
PRC2 , indicating that the interplay of PRC2 and JMJ fine-tunes deposition of the H3K27me3 mark
Pasini et al., Nature 2010
:
JARID2 regulates binding of the
Polycomb repressive complex 2 to target genes in ES cells
Li et al., Genes Dev 2010
:
Jarid2 can bind DNA and its recruitment in ES cells is interdependent with that of PRC2, as
Jarid2 knockdown
reduced PRC2 at its target promoters, and ES cells devoid of the PRC2 component EED are deficient in Jarid2 promoter access