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INS — PDE3A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PDE3A → INS (increases, INS Activity)
  Evidence: Insulin also profoundly inhibits lipolysis in adipocytes, primarily through inhibition of the enzyme hormone sensitive lipase71. This enzyme is acutely regulated by control of its phosphorylation state, which is activated by PKA-dependent phosphorylation, and inhibited as a result of a combination of kinase inhibition and phosphatase activation. Insulin inhibits the activity of the lipase primarily through reductions in cAMP levels, owing to the activation of a cAMP-specific phosphodiesterase in...

Text-mined interactions from Literome

Sadler et al., Mol Endocrinol 1991 : This pharmacological evidence demonstrates a necessary role for PDE III in insulin- , IGF-I-, and p21ras induced meiotic cell division in Xenopus laevis oocytes
Parker et al., Biochem Biophys Res Commun 1995 : Selective inhibition of PDE III stimulated insulin secretion, but inhibition of PDE IV had no effect