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GRB10 — INS

Pathways - manually collected, often from reviews:

• NCI Pathway Database Insulin Pathway: GRB10 (GRB10) → Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: GRB10 (GRB10) → Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) → p62DOK (DOK1) (modification, inhibits) Wick et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) → Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) (modification, inhibits)
  Wick et al., J Biol Chem 2001
  Evidence: assay
• Reactome Reaction: GRB10 → INS (indirect_complex) Wick et al., J Biol Chem 2003*, Langlais et al., Mol Endocrinol 2004*
• Reactome Reaction: GRB10 → INS (reaction) Wick et al., J Biol Chem 2003*, Langlais et al., Mol Endocrinol 2004*

Text-mined interactions from Literome

Lopaczynski et al., Acta biochimica Polonica 1999 : These studies raise the possibility that 14-3-3 and Grb10 may play a role in insulin and IGF-I signal transduction and may underlie the observed differences
Wang et al., Mol Cell Biol 1999 : ( i ) Complete Grb10 expression from cDNA with an ecdysone regulated transient expression system stimulated PDGF-BB-, IGF-I, and insulin- but not epidermal growth factor (EGF) induced DNA synthesis in an ecdysone dose-responsive fashion
Mori et al., Mol Cell Endocrinol 2005 : The adapter protein Grb10 binds to phosphotyrosine residues in insulin receptors via its C-terminal region and regulates insulin signaling
Holt et al., Biochem J 2005 (Genetic Predisposition to Disease) : Binding of Grb10 or Grb14 to autophosphorylated IR in vitro inhibits tyrosine kinase activity towards other substrates, but studies on cultured cell lines have been conflicting as to whether Grb10 plays a positive or negative role in insulin signalling
Langlais et al., Biochemistry 2005 : Taken together, our findings suggest that phosphorylation of the adaptor protein may provide a feedback inhibitory mechanism by which Grb10 regulates insulin signaling
Wang et al., Mol Cell Biol 2007 (Body Weight) : In order to investigate the in vivo role of Grb10 in insulin signaling and action in the periphery, we generated Grb10 knockout mice by the gene trap technique and analyzed mice with maternal inheritance of the knockout allele ... Disruption of Grb10 gene expression in peripheral tissues had no significant effect on fasting glucose and insulin levels
Huang et al., J Biol Chem 2010 : In addition to inhibiting insulin receptor and IGF1R kinase activity by directly binding to the receptors, GRB10 can also negatively regulate insulin and IGF1 signaling by mediating insulin receptor and IGF1R degradation through ubiquitination
Skolnik et al., EMBO J 1993 : In this report we show that in response to insulin , GRB2 forms a stable complex with two tyrosine phosphorylated proteins