BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor:
MHC class II complex (HLA-DRA-HLA-DRB1)
→
CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1)
(modification, collaborate)
BioCarta the co-stimulatory signal during t-cell activation:
MHC class II complex (HLA-DRA-HLA-DRB1)
→
MHC II/TCR-CD3 complex (CD3G-HLA-DRB1-TRA@-CD3D-TRB@-HLA-DRA-CD3E-CD3Z)
(modification, collaborate)